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SERUM DETERMINATION OF MMP-2 AND MMP-9 ACCORDING TO THE PATTERN OF ALCOHOL CONSUMPTION AND IN ALCOHOLIC HEPATIC DISEASE

The damage caused by alcohol consumption generates liver fibrosis, which is characterized by the accumulation of extracellular matrix (ECM); To limit the liver damage, MMP-2 and MMP-9 gelatinases are produced as mediators to degrade ECM products. Their importance in liver damage proposes them as pos...

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Bibliographic Details
Published in:Annals of hepatology 2022-01, Vol.27, p.100640, Article 100640
Main Authors: Hernandez-Barragan, A., Martinez-Castillo, M., Pérez-Hernández, J.L., la Tijera, F. Higuera-De, Santana-Vargas, D., Kershenobich, D., Gutiérrez-Reyes, G.
Format: Article
Language:English
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Summary:The damage caused by alcohol consumption generates liver fibrosis, which is characterized by the accumulation of extracellular matrix (ECM); To limit the liver damage, MMP-2 and MMP-9 gelatinases are produced as mediators to degrade ECM products. Their importance in liver damage proposes them as possible markers and target molecules in the diagnosis of alcohol consumption, as well as in alcoholic liver disease [1]. The objective of this work is to evaluate the serum concentrations of MMP-2 and MMP-9 gelatinases in subjects with different patterns of alcohol consumption and in alcoholic liver disease patients. A cross-sectional study was carried out in which subjects with different patterns of alcohol consumption were included. The inclusion was according to the AUDIT, DSM-IV, and clinical and biochemical data of liver disease: risk (Ri), abuse (Ab), dependence (OH), cirrhosis due to alcohol (CiOH) and alcoholic hepatitis (HA). A group without alcohol consumption (TC) was also included for comparison. For the quantification of MMP-2 and MMP-9, a multiple suspension assay (Milliplex®-MERCK ©) was used. Statistical analysis was performed using SPSS V.22 software using Mann Whitney U. P
ISSN:1665-2681
2659-5982
DOI:10.1016/j.aohep.2021.100640