Diet, Microbiota, and Colorectal Cancer

The intestinal epithelium is a very dynamic tissue under a high regenerative pressure, which makes it susceptible to malignant transformation. Proper integration of various cell signaling pathways and a balanced cross talk between different cell types composing the organ are required to maintain int...

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Bibliographic Details
Published in:iScience 2019-11, Vol.21, p.168-187
Main Authors: Grazioso, Tatiana P., Brandt, Marta, Djouder, Nabil
Format: Article
Language:English
Subjects:
Biological Sciences
Cancer
Microbiome
Review
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Summary:The intestinal epithelium is a very dynamic tissue under a high regenerative pressure, which makes it susceptible to malignant transformation. Proper integration of various cell signaling pathways and a balanced cross talk between different cell types composing the organ are required to maintain intestinal homeostasis. Dysregulation of this balance can lead to colorectal cancer (CRC). Here, we review important insights into molecular and cellular mechanisms of CRC. We discuss how perturbation in complex regulatory networks, including the Wnt, Notch, BMP, and Hedgehog pathways; and how variations in inflammatory signaling, nutrients, and microbiota can affect intestinal homeostasis contributing to the malignant transformation of intestinal cells. [Display omitted] Biological Sciences; Microbiome; Cancer
ISSN:2589-0042
2589-0042
DOI:10.1016/j.isci.2019.10.011