Effect of leaf essential oil from Piper solmsianum C.DC. in mice behaviour

The essential oil from Piper solmsianum leaves and its major compound (sarisan) were tested to verify their influences upon mice behaviour. The essential oil was obtained by hydrodistillation in a modified Clevenger extractor and analysed by GC/ MS. This analysis revealed in the oil the presence of...

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Bibliographic Details
Published in:Anais da Academia Brasileira de Ciências 2001-03, Vol.73 (1), p.33-57
Main Authors: Moreira, D L, Souza, P O, Kaplan, M A, Pereira, N A, Cardoso, G L, Guimarães, E F
Format: Article
Language:English
Subjects:
Akathisia, Drug-Induced - physiopathology
Animals
Antifungal Agents - pharmacology
Behavior, Animal - drug effects
Depression - chemically induced
Diazepam - pharmacology
Dioxolanes - pharmacology
essential oil
Female
Hypnotics and Sedatives - pharmacology
Male
Mice
MULTIDISCIPLINARY SCIENCES
Oils, Volatile - pharmacology
Pentobarbital - pharmacology
Piper solmsianum
Piperaceae
Plant Leaves
Plant Oils - pharmacology
psicofarmacologia
psychopharmacologic effect
sarisan
óleo essencial
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Summary:The essential oil from Piper solmsianum leaves and its major compound (sarisan) were tested to verify their influences upon mice behaviour. The essential oil was obtained by hydrodistillation in a modified Clevenger extractor and analysed by GC/ MS. This analysis revealed in the oil the presence of monoterpenes, sesquiterpenes and of arylpropanoids. The compound sarisan, a myristicin analogue, was isolated from the oil to perform the pharmacological tests. Emulsions of the oil and of sarisan (5.0 and 10.0% v/v) were used in the tests. Pentobarbital (30 mg/ kg s.c.) or diazepam (2.5 mg/ kg s.c.) were tested as standard drugs to verify depressant or anxiolytic effects, respectively. Both essential oil and sarisan showed to have exciting and depressant effects in the tested animals.
ISSN:0001-3765
1678-2690
0001-3765
1678-2690
DOI:10.1590/S0001-37652001000100004