Progress of Nanomaterials-Based Photothermal Therapy for Oral Squamous Cell Carcinoma

Oral squamous cell carcinoma (OSCC) is one of the top 15 most prevalent cancers worldwide. However, the current treatment models for OSCC (e.g., surgery, chemotherapy, radiotherapy, and combination therapy) present several limitations: damage to adjacent healthy tissue, possible recurrence, low effi...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-09, Vol.23 (18), p.10428
Main Authors: Niu, Qin, Sun, Qiannan, Bai, Rushui, Zhang, Yunfan, Zhuang, Zimeng, Zhang, Xin, Xin, Tianyi, Chen, Si, Han, Bing
Format: Article
Language:English
Subjects:
Biocompatibility
Cancer therapies
Chemotherapy
Cytotoxicity
Drug delivery
drug delivery system
Drug delivery systems
Efficiency
Experiments
Gold
Heat
Hyperthermia
Lasers
Light
Medical research
Metal compounds
Micelles
Nanomaterials
Nanoparticles
Nanotechnology
Noble metals
Oral cancer
Oral carcinoma
Oral squamous cell carcinoma
photothermal conversion agents
photothermal therapy
Polyethylene glycol
Radiation therapy
Review
Squamous cell carcinoma
Surgery
Toxicity
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Summary:Oral squamous cell carcinoma (OSCC) is one of the top 15 most prevalent cancers worldwide. However, the current treatment models for OSCC (e.g., surgery, chemotherapy, radiotherapy, and combination therapy) present several limitations: damage to adjacent healthy tissue, possible recurrence, low efficiency, and severe side effects. In this context, nanomaterial-based photothermal therapy (PTT) has attracted extensive research attention. This paper reviews the latest progress in the application of biological nanomaterials for PTT in OSCC. We divide photothermal nanomaterials into four categories (noble metal nanomaterials, carbon-based nanomaterials, metal compounds, and organic nanomaterials) and introduce each category in detail. We also mention in detail the drug delivery systems for PTT of OSCC and briefly summarize the applications of hydrogels, liposomes, and micelles. Finally, we note the challenges faced by the clinical application of PTT nanomaterials and the possibility of further improvement, providing direction for the future research of PTT in OSCC treatment.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms231810428