Sericin for Tissue Engineering

Sericin is a 10-to-400 kDa hydrophilic protein with high serine content and is a silk constituent together with fibroin. It is produced in the middle silk gland of the silkworm and encoded by four sericin genes. The molecular weight of sericin and its biological activity vary depending on the extrac...

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Bibliographic Details
Published in:Applied sciences 2020-12, Vol.10 (23), p.8457
Main Authors: Jo, You-Young, Kweon, HaeYong, Oh, Ji-Hyeon
Format: Article
Language:English
Subjects:
Amino acids
Biocompatibility
Biological activity
Biological properties
Bombyx mori
Bone growth
Cartilage
degumming method
Drug delivery
Drug delivery systems
Genes
Inflammation
Molecular weight
Proteins
Random coil
Regeneration
Regeneration (physiology)
sericin
Serine
Silk
Silk gland
Silkworms
Textile fibers
Textile industry
Tissue engineering
Vascular endothelial growth factor
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Description
Summary:Sericin is a 10-to-400 kDa hydrophilic protein with high serine content and is a silk constituent together with fibroin. It is produced in the middle silk gland of the silkworm and encoded by four sericin genes. The molecular weight of sericin and its biological activity vary depending on the extraction method employed. Its chemical structure, in terms of random coil and β-sheet conformations, also differs with the extraction method, thereby extending its applications in various fields. Sericin, which was discarded in the textile industry in the past, is being applied and developed in the biomedical field, owing to its biological properties. In particular, many studies are underway in the field of tissue engineering, evaluating its applicability in burn dressing, drug delivery, bone regeneration, cartilage regeneration, and nerve regeneration.
ISSN:2076-3417
2076-3417
DOI:10.3390/app10238457