MiR-9 and the Midbrain-Hindbrain Boundary: A Showcase for the Limited Functional Conservation and Regulatory Complexity of MicroRNAs

MicroRNAs regulate gene expression at post-transcriptional levels. Some of them appear to regulate brain development and are involved in neurodevelopmental disorders. This has led to the suggestion that the role of microRNAs in neuronal development and function may be more central than previously ap...

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Bibliographic Details
Published in:Frontiers in cell and developmental biology 2020-11, Vol.8, p.586158-586158
Main Authors: Alwin Prem Anand, A, Alvarez-Bolado, Gonzalo, Wizenmann, Andrea
Format: Article
Language:English
Subjects:
Cell and Developmental Biology
danio
Fgf8
gallus
mid-hindbrain boundary
neural development
xenopus
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Summary:MicroRNAs regulate gene expression at post-transcriptional levels. Some of them appear to regulate brain development and are involved in neurodevelopmental disorders. This has led to the suggestion that the role of microRNAs in neuronal development and function may be more central than previously appreciated. Here, we review the data about miR-9 function to depict the subtlety, complexity, flexibility and limited functional conservation of this essential developmental regulatory system. On this basis we propose that species-specific actions of miR-9 could underlie to a large degree species differences in brain size, shape and function.
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2020.586158