Lipid Traffic Analysis reveals the impact of high paternal carbohydrate intake on offsprings’ lipid metabolism

In this paper we present an investigation of parental-diet-driven metabolic programming in offspring using a novel computational network analysis tool. The impact of high paternal carbohydrate intake on offsprings’ phospholipid and triglyceride metabolism in F1 and F2 generations is described. Detai...

Full description

Saved in:
Bibliographic Details
Published in:Communications biology 2021-02, Vol.4 (1), p.163-163, Article 163
Main Authors: Furse, Samuel, Watkins, Adam J., Hojat, Nima, Smith, James, Williams, Huw E. L., Chiarugi, Davide, Koulman, Albert
Format: Article
Language:English
Subjects:
101/58
631/114/2398
631/136/2435
631/92/608
Adipose tissue
Biology
Biomedical and Life Sciences
Carbohydrate metabolism
Carbohydrates
Computational neuroscience
Dietary intake
Fat metabolism
Life Sciences
Lipid metabolism
Lipids
Metabolism
Offspring
Phospholipids
Spatial distribution
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this paper we present an investigation of parental-diet-driven metabolic programming in offspring using a novel computational network analysis tool. The impact of high paternal carbohydrate intake on offsprings’ phospholipid and triglyceride metabolism in F1 and F2 generations is described. Detailed lipid profiles were acquired from F1 neonate (3 weeks), F1 adult (16 weeks) and F2 neonate offspring in serum, liver, brain, heart and abdominal adipose tissues by MS and NMR. Using a purpose-built computational tool for analysing both phospholipid and fat metabolism as a network, we characterised the number, type and abundance of lipid variables in and between tissues (Lipid Traffic Analysis), finding a variety of reprogrammings associated with paternal diet. These results are important because they describe the long-term metabolic result of dietary intake by fathers. This analytical approach is important because it offers unparalleled insight into possible mechanisms for alterations in lipid metabolism throughout organisms. Furse et al. use a purpose-built computational tool called Lipid Traffic Analysis to determine the spatial distribution of lipids throughout an organism. They use it to show that high paternal carbohydrate intake influences lipid metabolism in offspring two generations hence.
ISSN:2399-3642
2399-3642
DOI:10.1038/s42003-021-01686-1