Role of the Circadian Gas-Responsive Hemeprotein NPAS2 in Physiology and Pathology

Neuronal PAS domain protein 2 (NPAS2) is a hemeprotein comprising a basic helix–loop–helix domain (bHLH) and two heme-binding sites, the PAS-A and PAS-B domains. This protein acts as a pyridine nucleotide-dependent and gas-responsive CO-dependent transcription factor and is encoded by a gene whose e...

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Bibliographic Details
Published in:Biology (Basel, Switzerland) Switzerland), 2023-10, Vol.12 (10), p.1354
Main Authors: Murgo, Emanuele, Colangelo, Tommaso, Bellet, Maria Marina, Malatesta, Francesco, Mazzoccoli, Gianluigi
Format: Article
Language:English
Subjects:
Amino acids
Carcinogenesis
Central nervous system
Cerebrovascular diseases
circadian
Circadian rhythm
Circadian rhythms
Feedback
Genes
Genetic transcription
Heme
Heme proteins
Hydrocarbons
Hypothalamus
Implants, Artificial
Medical innovations
Mental disorders
Metabolic pathways
molecular clockwork
Nervous system
Neurons
NPAS2
NPAS2 protein
PAS domain
Peptides
Physiological aspects
Physiology
Prosthesis
Proteins
Review
rhythmicity
Sleep and wakefulness
Sleep disorders
Transcription factors
Vascular diseases
Wound healing
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Summary:Neuronal PAS domain protein 2 (NPAS2) is a hemeprotein comprising a basic helix–loop–helix domain (bHLH) and two heme-binding sites, the PAS-A and PAS-B domains. This protein acts as a pyridine nucleotide-dependent and gas-responsive CO-dependent transcription factor and is encoded by a gene whose expression fluctuates with circadian rhythmicity. NPAS2 is a core cog of the molecular clockwork and plays a regulatory role on metabolic pathways, is important for the function of the central nervous system in mammals, and is involved in carcinogenesis as well as in normal biological functions and processes, such as cardiovascular function and wound healing. We reviewed the scientific literature addressing the various facets of NPAS2 and framing this gene/protein in several and very different research and clinical fields.
ISSN:2079-7737
2079-7737
DOI:10.3390/biology12101354