Removal of Mefenamic Acid from Aqueous Solution by Fenton Process: Optimization Using Response Surface Methodology with Central Composite Design

In the present study, the three main process parameters in the Fenton process for the removal of pharmaceutical compound Mefenamic acid from an aqueous solution were optimized using response surface methodology (RSM). Central composite design (CCD) was used for process optimization. The primary and...

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Bibliographic Details
Published in:Nature environment and pollution technology 2021-12, Vol.20 (5), p.2061-2067
Main Authors: Deepa, R., Madhu, G., Thomas, Roy M, Achari, V. Sivanandan
Format: Article
Language:English
Subjects:
Acids
Activated carbon
Adsorption
Aqueous solutions
Catalysts
Design optimization
Efficiency
Experiments
Hydrogen peroxide
Iron
Mathematical models
Mefenamic acid
mefenamic acid, fenton process, hydroxyl radical, response surface methodology
Oxidation
pH effects
Pollutants
Process parameters
Response surface methodology
Solvents
Variables
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Summary:In the present study, the three main process parameters in the Fenton process for the removal of pharmaceutical compound Mefenamic acid from an aqueous solution were optimized using response surface methodology (RSM). Central composite design (CCD) was used for process optimization. The primary and secondary interaction effects of the selected parameters such as H2O2, Fe2+ and pH on the removal of mefenamic acid were examined. A mathematical model for the removal process based on the selected variables was developed. The interaction effect between the chosen parameters shows that the removal of mefenamic acid was enhanced in the acidic pH range at a high concentration of H2O2 and in a medium concentration level of the catalyst Fe2+. The removal efficiency of 81.24% was obtained for mefenamic acid at the optimized condition of variables such as 9.36 mM H2O2, 0.058 mM Fe2+and at a pH value of 2.1.
ISSN:0972-6268
2395-3454
DOI:10.46488/NEPT.2021.v20i05.023