Early thrombus detection in the extracorporeal membrane oxygenation circuit by noninvasive real-time ultrasonic sensors

Thrombus formation in extracorporeal membrane oxygenation (ECMO) remains a major concern as it can lead to fatal outcomes. To the best of our knowledge, there is no standard non-invasive method for quantitatively measuring thrombi. This study’s purpose was to verify thrombus detection in an ECMO cir...

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Bibliographic Details
Published in:Scientific reports 2024-05, Vol.14 (1), p.10438-10438, Article 10438
Main Authors: Rim, Gongmin, Hyun, Kwanyong, Cho, Deog Gon, Lim, Zhongsoo, Lee, Byungdoo, Kim, Keunho, Yoo, Ga young
Format: Article
Language:English
Subjects:
631/57
692/4019
Animals
Blood
Blood clots
Extracorporeal membrane oxygenation
Extracorporeal Membrane Oxygenation - instrumentation
Extracorporeal Membrane Oxygenation - methods
Humanities and Social Sciences
multidisciplinary
Oxygenation
Real-time non-invasive thrombus detection
Science
Science (multidisciplinary)
Sensors
Swine
Thrombosis
Thrombosis - diagnosis
Thrombosis - diagnostic imaging
Thrombus
Travel time difference
Ultrasonic sensors
Ultrasonics
Ultrasonography - methods
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Summary:Thrombus formation in extracorporeal membrane oxygenation (ECMO) remains a major concern as it can lead to fatal outcomes. To the best of our knowledge, there is no standard non-invasive method for quantitatively measuring thrombi. This study’s purpose was to verify thrombus detection in an ECMO circuit using novel, non-invasive ultrasonic sensors in real-time, utilizing the fact that the ultrasonic velocity in a thrombus is known to be higher than that in the blood. Ultrasonic sensors with a customized chamber, an ultrasonic pulse-receiver, and a digital storage oscilloscope (DSO) were used to set up the measuring unit. The customized chamber was connected to an ECMO circuit primed with porcine blood. Thrombi formed from static porcine blood were placed in the circuit and ultrasonic signals were extracted from the oscilloscope at various ECMO flow rates of 1–4 L/min. The ultrasonic signal changes were successfully detected at each flow rate on the DSO. The ultrasonic pulse signal shifted leftward when a thrombus passed between the two ultrasonic sensors and was easily detected on the DSO screen. This novel real-time non-invasive thrombus detection method may enable the early detection of floating thrombi in the ECMO system and early management of ECMO thrombi.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-59873-z