Age-Associated Changes of Sirtuin 2 Expression in CNS and the Periphery

Sirtuin 2 (SIRT2), one of the seven members of the sirtuin family, has emerged as a potential regulator of aging and age-related pathologies since several studies have demonstrated that it shows age-related changes in humans and different animal models. A detailed analysis of the relevant works publ...

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Bibliographic Details
Published in:Biology (Basel, Switzerland) Switzerland), 2023-11, Vol.12 (12), p.1476
Main Authors: Garmendia-Berges, Maider, Sola-Sevilla, Noemi, Mera-Delgado, MCarmen, Puerta, Elena
Format: Article
Language:English
Subjects:
Age
Aging
Analysis
Animal models
brain
Brain research
Cardiovascular diseases
Cell cycle
DNA methylation
Epigenetics
Gene expression
Geriatrics
Health aspects
Hypotheses
inflammation
Insulin resistance
Kinases
Life expectancy
Life span
Medical research
Medicine, Experimental
Metabolism
Molecular modelling
Nervous system diseases
Neurodegenerative diseases
Neurophysiology
Older people
Oxidative stress
Physiology
Proteins
Senescence
sirtuin 2
Spinal cord
Transcription factors
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Summary:Sirtuin 2 (SIRT2), one of the seven members of the sirtuin family, has emerged as a potential regulator of aging and age-related pathologies since several studies have demonstrated that it shows age-related changes in humans and different animal models. A detailed analysis of the relevant works published to date addressing this topic shows that the changes that occur in SIRT2 with aging seem to be opposite in the brain and in the periphery. On the one hand, aging induces an increase in SIRT2 levels in the brain, which supports the notion that its pharmacological inhibition is beneficial in different neurodegenerative diseases. However, on the other hand, in the periphery, SIRT2 levels are reduced with aging while keeping its expression is protective against age-related peripheral inflammation, insulin resistance, and cardiovascular diseases. Thus, systemic administration of any known modulator of this enzyme would have conflicting outcomes. This review summarizes the currently available information on changes in SIRT2 expression in aging and the underlying mechanisms affected, with the aim of providing evidence to determine whether its pharmacological modulation could be an effective and safe pharmacological strategy for the treatment of age-related diseases.
ISSN:2079-7737
2079-7737
DOI:10.3390/biology12121476