Tranexamic Acid Administered During Off-Pump Coronary Artery Bypass Graft Surgeries Achieves Good Safety Effects and Hemostasis

Tranexamic acid (TXA) administered during off-pump coronary artery bypass (OPCAB) surgeries has achieved good blood control in small cohorts. We aimed to investigate the safety issues and hemostasis associated with TXA administration during OPCAB in a large retrospective cohort study. This study inc...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in cardiovascular medicine 2022-02, Vol.9, p.775760
Main Authors: Wang, Enshi, Yuan, Xin, Wang, Yang, Chen, Weinan, Zhou, Xingtong, Hu, Shengshou, Yuan, Su
Format: Article
Language:English
Subjects:
blood transfusion
Cardiovascular Medicine
off-pump coronary artery bypass grafting
propensity score matching
risk analysis
thromboembolism
tranexamic acid
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Tranexamic acid (TXA) administered during off-pump coronary artery bypass (OPCAB) surgeries has achieved good blood control in small cohorts. We aimed to investigate the safety issues and hemostasis associated with TXA administration during OPCAB in a large retrospective cohort study. This study included 19,687 patients with OPCAB from 2009 to 2019. A total of 1,307 patients were excluded because they were younger than 18 years or certain values were missing. Among the remaining 18,380 patients, 10,969 were in the TXA group and 7,411 patients were in the no-TXA group. There were 4,889 patients whose TXA dose was ≥50 mg/kg, and the remaining 6,080 patients had a TXA dose of
ISSN:2297-055X
2297-055X
DOI:10.3389/fcvm.2022.775760