sFlt-1, Not PlGF, Is Related to Twin Gestation Choronicity in the First and Third Trimesters of Pregnancy

Background: Preeclampsia occurs more often in dichorionic than in monochorionic twin pregnancy. We hypothesize that serum concentrations of biomarkers: placental growth factor (PlGF), serum soluble fms-like tyrosine kinase-1 (sFlt-1), and endoglin (Eng) differ between monochorionic and dichorionic t...

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Published in:Diagnostics (Basel) 2021-06, Vol.11 (7), p.1181
Main Authors: Kozłowski, Szymon, Stelmaszczyk-Emmel, Anna, Szymusik, Iwona, Saletra-Bielińska, Aleksandra, Brawura-Biskupski-Samaha, Robert, Pietruski, Paweł, Osińska, Agnieszka, Kosińska-Kaczyńska, Katarzyna
Format: Article
Language:English
Subjects:
Biomarkers
chorionicity
Cloning
Gestational age
Gynecology
Medical education
Obstetrics
PlGF
Preeclampsia
Pregnancy
sEng
sFlt-1
twin pregnancy
Ultrasonic imaging
Vascular endothelial growth factor
Womens health
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Summary:Background: Preeclampsia occurs more often in dichorionic than in monochorionic twin pregnancy. We hypothesize that serum concentrations of biomarkers: placental growth factor (PlGF), serum soluble fms-like tyrosine kinase-1 (sFlt-1), and endoglin (Eng) differ between monochorionic and dichorionic twin pregnancies. Methods: A prospective observational study including 43 monochorionic and 36 dichorionic twin gestation was conducted. Blood samples were collected twice from all participants: between 11 + 0 and 13 + 6 and between 32 + 0 and 34 + 0 weeks of gestation. PlGF, sFlt-1 and Eng were measured using immnunoenzymatic assays. Results: We found a significantly higher concentration of sFlt-1 in dichorionic in comparison to monochorionic pregnancies in both the first and third trimesters. PlGF and sEng levels did not differ between mono- and dichorionic gestation in both study periods. sFlt-1 level was related to twin gestation chorionicity, while PlGF expression was not. PlGF, sFlt-1 and sEng concentrations increased significantly during gestation and were much higher in the third trimester compared to the values measured in the first trimester. Conclusions: Angiogenic biomarkers expression differ between dichorionic and monochorionic twin pregnancy. The sFlt-1 level is related to chorionicity of a twin gestation.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics11071181