Protective effects of Zizyphus oxyphyla on liver and kidney related serum biomarkers in (CCl4) intoxicate rabbits

• Published in: Brazilian journal of biology 2023, Vol.83, p.1-10
• Main Authors: Ahmad, B., Ilahi, I., Yousafzai, A. M., Attaullah, M., Rahim, A., Naz, D., Hazrat, A., Batiha, G. E-S., Nassan, M. A., Khalil, A. A. K.
• Format: Article
• Language: English
• Subjects: 2-diphenile-1-picrylehydrazyle (DPPH); Alanine; Alanine transaminase; Albumins; Alkaline phosphatase; Antioxidants; Aspartate transaminase; BIOLOGY; Biomarkers; Blood; Body weight; Calcium; Carbon; Carbon tetrachloride; Creatinine; Dosage; Drug dosages; Electrolytes; Equivalence; Free radicals; hematological parameters; Hematology; hepatoprotective; Ingestion; Intoxication; Kidneys; Laboratory animals; Lipids; Liver; Magnesium; methanol extract; Normalizing; Phosphatase; Rabbits; Scavenging; serum levels; Toxicity; Transaminase; Urea; Uric acid; ZOX-LME
• ISSN: 1519-6984; 1678-4375; 1678-4375
• DOI: 10.1590/1519-6984.246980

Abstract The study was aimed to evaluate the therapeutic effects of Zizyphus oxyphyla leaves methanolic (ZOX-LME), on serum liver, kidney and hematology along with other serum parameters in Carbon tetrachloride (CCl4) intoxicated rabbits. Experimental animals were divided into five groups, six rabbits in each. These were: group NC (normal control), group, TC (toxic control) and group ST i.e. silymarine administered group at dose rate (50) mg/kg body weight (BW). Group ET1 and group ET2 treated with (ZOX-LME) at dose 200 mg/kg BW and 400 mg/kg BW. CCl4 administration caused significant (P> 0.05) impairment in serum liver enzymes, blood factors and other serum indices. Treatment with (ZOX-LME) significantly (P