Improvement of quality of life and symptom burden after robot-assisted radical prostatectomy in patients with moderate to severe LUTS

• Published in: Scientific reports 2021-08, Vol.11 (1), p.16757-16757, Article 16757
• Main Authors: Leyh-Bannurah, Sami-Ramzi, Wagner, Christian, Schuette, Andreas, Liakos, Nikolaos, Karagiotis, Theodoros, Mendrek, Mikolaj, Rachubinski, Pawel, Urbanova, Katarina, Oelke, Matthias, Witt, Jorn H.
• Format: Article
• Language: English
• Subjects: 692/4025/1752; 692/4025/2768/1753; 692/4025/2768/2767; Humanities and Social Sciences; multidisciplinary; Prostate; Prostatectomy; Quality of life; Robots; Science; Science (multidisciplinary); Urinary tract; Urological surgery
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-95525-2

The aim of this study was to assess clinically meaningful differences of preoperative lower urinary tract symptoms (LUTS) and quality of life (QoL) before and after robot-assisted radical prostatectomy (RARP). Therefore we identified 5506 RARP patients from 2007 to 2018 with completed International Prostate Symptom Score (IPSS) and -QoL questionnaires before and 12 months after RARP in our institution. Marked clinically important difference (MCID) was defined by using the strictest IPSS-difference of − 8 points. Multivariable logistic regression analyses (LRM) aimed to predict ∆IPSS ≤ − 8 and were restricted to RARP patients with preoperatively moderate (IPSS 8–19) vs. severe (IPSS 20–35) LUTS burden (n = 2305). Preoperative LUTS was categorized as moderate and severe in 37% (n = 2014) and 5.3% of the complete cohort (n = 291), respectively. Here, a postoperative ∆IPSS ≤ − 8, was reported in 38% vs. 90%. In LRM, younger age (OR 0.98, 95%CI 0.97–0.99; p = 0.007), lower BMI (OR 0.94, 95%CI 0.92–0.97; p