Maternal Vitamin D and Newborn Telomere Length

Nutrition is important during pregnancy for offspring health. Gestational vitamin D intake may prevent several adverse outcomes and might have an influence on offspring telomere length (TL). In this study, we want to assess the association between maternal vitamin D intake during pregnancy and newbo...

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Bibliographic Details
Published in:Nutrients 2021-06, Vol.13 (6), p.2012
Main Authors: Daneels, Lisa, Martens, Dries S, Arredouani, Soumia, Billen, Jaak, Koppen, Gudrun, Devlieger, Roland, Nawrot, Tim S, Ghosh, Manosij, Godderis, Lode, Pauwels, Sara
Format: Article
Language:English
Subjects:
25-Hydroxyvitamin D
Alfacalcidol
Blood
Calcifediol
Calciferol
Cord blood
Diet
Dietary intake
DNA methylation
Ethylenediaminetetraacetic acid
Genetic testing
Human nutrition
Infants (Newborn)
Mothers
newborn
Newborn babies
Nutrition
Nutrition research
Offspring
Pregnancy
telomere length
Telomeres
Vitamin D
Vitamin deficiency
Womens health
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Summary:Nutrition is important during pregnancy for offspring health. Gestational vitamin D intake may prevent several adverse outcomes and might have an influence on offspring telomere length (TL). In this study, we want to assess the association between maternal vitamin D intake during pregnancy and newborn TL, as reflected by cord blood TL. We studied mother–child pairs enrolled in the Maternal Nutrition and Offspring’s Epigenome (MANOE) cohort, Leuven, Belgium. To calculate the dietary vitamin D intake, 108 women were asked to keep track of their diet using the seven-day estimated diet record (EDR) method. TL was assessed in 108 cord blood using a quantitative real-time PCR method. In each trimester of pregnancy, maternal serum 25-hydroxyvitamin D (25-OHD) concentration was measured. We observed a positive association (β = 0.009, p-value = 0.036) between newborn average relative TL and maternal vitamin D intake (diet + supplement) during the first trimester. In contrast, we found no association between average relative TL of the newborn and mean maternal serum 25-OHD concentrations during pregnancy. To conclude, vitamin D intake (diet + supplements), specifically during the first trimester of pregnancy, is an important factor associated with TL at birth.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu13062012