Ki67 Labelling Index predicts clinical outcome and survival in oral squamous cell carcinoma

To investigate the Ki 67 expression and its correlation with clinicopathological features and 3 years as well as 5 years survival rate in oral squamous cell carcinoma (OSCC). Total 217cases of OSCC primarily treated with surgery with or without radiation were included. All patients were followed up...

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Bibliographic Details
Published in:Journal of applied oral science 2021-01, Vol.29, p.e20200751-e20200751
Main Authors: Gadbail, Amol Ramchandra, Sarode, Sachin C, Chaudhary, Minal S, Gondivkar, Shailesh M, Tekade, Satyajit Ashok, Yuwanati, Monal, Patil, Shankargouda
Format: Article
Language:English
Subjects:
Biomarkers, Tumor
Carcinoma, Squamous Cell
Dentistry
DENTISTRY, ORAL SURGERY & MEDICINE
Head and Neck Neoplasms
Humans
Ki-67 Antigen
Ki67 Labelling Index
Mouth Neoplasms
Oral Squamous Cell Carcinoma
Original
Prognosis
Proliferation
Squamous Cell Carcinoma of Head and Neck
Survival
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Summary:To investigate the Ki 67 expression and its correlation with clinicopathological features and 3 years as well as 5 years survival rate in oral squamous cell carcinoma (OSCC). Total 217cases of OSCC primarily treated with surgery with or without radiation were included. All patients were followed up for 3 years and 150 were followed up of 5 years for disease free survival. The immunohistochemistry was carried out on neutral buffered formalin fixed paraffin embedded tissue to evaluate the expression of Ki67. The Ki67 labeling index (LI) was significantly higher with respect to adverse clinicopathological parameters such as histopathological grading (p
ISSN:1678-7757
1678-7765
1678-7765
DOI:10.1590/1678-7757-2020-0751