Investigation of acute organophosphate poisoning in humans based on sociodemographic and role of neurotransmitters with survival study in South India

The aim of this study was to investigate the sociodemographic characteristics of patients based on the poison chosen and different types of organophosphorus compounds. The data were collected to explore the sociodemographic characteristics of organophosphate (OP)-poisoned patients based on the sourc...

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Bibliographic Details
Published in:Scientific reports 2022-10, Vol.12 (1), p.16513-16513, Article 16513
Main Authors: Sinha, Sukesh Narayan, Kumpati, Rajesh Kumar, Ramavath, Pandu Naik, Sangaraju, Rajendra, Gouda, Balaji, Chougule, Priyanka
Format: Article
Language:English
Subjects:
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692/499
704/172
Dopamine
Humanities and Social Sciences
multidisciplinary
Neurotransmitters
Organophosphates
Organophosphorus compounds
Organophosphorus pesticides
Pesticides
Poisoning
Public health
Respiratory failure
Science
Science (multidisciplinary)
Serotonin
Sociodemographics
Survival
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Summary:The aim of this study was to investigate the sociodemographic characteristics of patients based on the poison chosen and different types of organophosphorus compounds. The data were collected to explore the sociodemographic characteristics of organophosphate (OP)-poisoned patients based on the source, site, and route of poisoning, education level, occupational status, and the purpose of poisoning. Furthermore, we estimated the serotonin and dopamine levels in the plasma samples of patients, and survival plots were also described. During the study of OP pesticide poisoning in 116 human subjects and 5 healthy volunteers, we observed, based on the survival plot, that75.9% of the patients were discharged, and the remaining patients died (24.1% of the patients) due to respiratory failure followed by cardiac arrest. Our findings suggest that the serotonin levels significantly ( p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-21054-1