Chemistry and Bioactivity of Briaranes from the South China Sea Gorgonian Dichotella gemmacea

Seven new briarane diterpenoids, gemmacolides AZ-BF ( - ), were isolated together with eight known analogues ( - ) from the South China gorgonian . Their structures were elucidated based on detailed spectroscopic analysis and a comparison with reported data. In an in vitro bioassay, these compounds...

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Published in:Marine drugs 2016-10, Vol.14 (11), p.201-201
Main Authors: Li, Cui, La, Ming-Ping, Tang, Hua, Sun, Peng, Liu, Bao-Shu, Zhuang, Chun-Lin, Yi, Yang-Hua, Zhang, Wen
Format: Article
Language:English
Subjects:
A549 Cells
Animals
Anthozoa - chemistry
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Bacillus megaterium
Bacillus megaterium - drug effects
biological activity
briarane diterpenoids
Cell Line, Tumor
China
Dichotella gemmacea
Diterpenes - chemistry
Diterpenes - pharmacology
Escherichia coli
Escherichia coli - drug effects
Gorgonacea
gorgonian
Humans
Marine
structure elucidation
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Summary:Seven new briarane diterpenoids, gemmacolides AZ-BF ( - ), were isolated together with eight known analogues ( - ) from the South China gorgonian . Their structures were elucidated based on detailed spectroscopic analysis and a comparison with reported data. In an in vitro bioassay, these compounds exhibited different levels of growth inhibition activity against A549 and MG63 cells, giving continuous evidences about the biological contribution of functional groups at C-2, C-12, C-13, and C-16. These compounds were also evaluated for their antibacterial and antifungal activities. Compound exhibited a potential antibacterial activity against both Gram-positive bacterium and Gram-negative bacterium .
ISSN:1660-3397
1660-3397
DOI:10.3390/md14110201