Duration of Reproductive Life Span, Age at Menarche, and Age at Menopause Are Associated With Risk of Cardiovascular Disease in Women

Background Although the timing of menarche and menopause may be associated with cardiovascular disease (CVD), the entire reproductive life span has not been considered comprehensively as risk for CVD. We investigate the associations of reproductive life span duration and ages at menarche and menopau...

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Bibliographic Details
Published in:Journal of the American Heart Association 2017-11, Vol.6 (11), p.n/a
Main Authors: Ley, Sylvia H., Li, Yanping, Tobias, Deirdre K., Manson, JoAnn E., Rosner, Bernard, Hu, Frank B., Rexrode, Kathryn M.
Format: Article
Language:English
Subjects:
age at menarche
cardiovascular disease
coronary heart disease
menopause
Original Research
reproductive life span
stroke
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Summary:Background Although the timing of menarche and menopause may be associated with cardiovascular disease (CVD), the entire reproductive life span has not been considered comprehensively as risk for CVD. We investigate the associations of reproductive life span duration and ages at menarche and menopause, induced by natural means or surgical bilateral oophorectomy, with incident CVD in women. Methods and Results Prospective cohort study of 73 814 Nurses' Health Study following participants without CVD, defined as incident coronary heart disease or stroke, from 1980 through 2012. Duration of reproductive life span was generated by subtracting age at menarche from age at menopause. A shorter reproductive life span was associated with a higher risk of incident CVD after multivariable adjustment (relative risk, 1.32 [95% confidence interval, 1.16–1.49] comparing duration
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.117.006713