Patient‐reported distress and age‐related stress biomarkers among colorectal cancer patients

Objective Distress among cancer patients has been broadly accepted as an important indicator of well‐being but has not been well studied. We investigated patient characteristics associated with high distress levels as well as correlations among measures of patient‐reported distress and “objective” s...

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Published in:Cancer medicine (Malden, MA) MA), 2021-06, Vol.10 (11), p.3604-3612
Main Authors: Eddington, Hyrum S., McLeod, Megan, Trickey, Amber W., Barreto, Nicolas, Maturen, Katherine, Morris, Arden M.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Age Factors
Aged
Anxiety
Anxiety - epidemiology
biomarker
Biomarkers
Biomarkers - analysis
Clinical Cancer Research
Clinical outcomes
Colon cancer
Colonic Neoplasms - psychology
Colorectal cancer
Colorectal carcinoma
Cortisol
Demography
Depression - epidemiology
distress
Female
Health Surveys
Hormones
Humans
Hydrocortisone - analysis
Linear Models
Male
Marital Status
Medicaid
Medicare
Mental depression
Middle Aged
Original Research
Patient Reported Outcome Measures
patient reported outcomes
Patients
Psoas Muscles - diagnostic imaging
Rectal Neoplasms - psychology
Rectum
Regression analysis
Saliva - chemistry
Sarcopenia
Sarcopenia - diagnostic imaging
Sex Factors
Social interactions
Statistical analysis
Stress, Psychological - epidemiology
Variables
Well being
Work stations
Young Adult
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Summary:Objective Distress among cancer patients has been broadly accepted as an important indicator of well‐being but has not been well studied. We investigated patient characteristics associated with high distress levels as well as correlations among measures of patient‐reported distress and “objective” stress‐related biomarkers among colorectal cancer patients. Methods In total, 238 patients with colon or rectal cancer completed surveys including the Distress Thermometer, Problem List, and the Hospital Anxiety and Depression Scale. We ed demographic and clinical information from patient charts and determined salivary cortisol level and imaging‐based sarcopenia. We evaluated associations between patient characteristics (demographics, clinical factors, and psychosocial and physical measures) and three outcomes (patient‐reported distress, cortisol, and sarcopenia) with Spearman's rank correlations and multivariable linear regression. The potential moderating effect of age was separately investigated by including an interaction term in the regression models. Results Patient‐reported distress was associated with gender (median: women 5.0, men 3.0, p 
ISSN:2045-7634
2045-7634
DOI:10.1002/cam4.3914