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Red blood cell distribution width as a prognostic factor in patients with aplastic anemia treated with cyclosporin A plus androgen or cyclosporine A alone: a retrospective study

OBJECTIVETo explore the prognostic value of red blood cell distribution width (RDW) in newly diagnosed aplastic anemia (AA) patients treated with cyclosporine A (CsA) plus androgen or CsA alone. METHODSWe retrospectively analyzed the clinical outcome of 220 patients with AA. According to the baselin...

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Published in:	Hematology (Luxembourg) 2023-12, Vol.28 (1), p.2240665-2240665
Main Authors:	Zhang, Xiaotian, Zhang, Yanan, Liu, Fengan, Zhu, Jingjing, Liang, Xiuli, Shi, Xuedong, Han, Li, Xu, Kailin, Cheng, Hai
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Language:	English
Subjects:	androgen Aplastic anemia cyclosporin A prognostic factor red blood cell distribution width treatment
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creator	Zhang, Xiaotian Zhang, Yanan Liu, Fengan Zhu, Jingjing Liang, Xiuli Shi, Xuedong Han, Li Xu, Kailin Cheng, Hai
description	OBJECTIVETo explore the prognostic value of red blood cell distribution width (RDW) in newly diagnosed aplastic anemia (AA) patients treated with cyclosporine A (CsA) plus androgen or CsA alone. METHODSWe retrospectively analyzed the clinical outcome of 220 patients with AA. According to the baseline level of RDW before treatment, the patients were divided into the high-RDW group (RDW ≥ 15%) and the normal-RDW group (RDW
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METHODSWe retrospectively analyzed the clinical outcome of 220 patients with AA. According to the baseline level of RDW before treatment, the patients were divided into the high-RDW group (RDW ≥ 15%) and the normal-RDW group (RDW < 15%). RESULTSThe median RDW of non-severe AA (NSAA) and severe AA (SAA) patients was 15.65% and 15.35%, respectively; this were significantly higher than that of very severe AA (VSAA) patients (13.35%). With median follow-up being 46 months, AA patients in the high-RDW group showed better 5-year OS and PFS than the normal-RDW group (93%: 75.3%; 74.3%: 61%). There was a higher ORR in the high-RDW group than the normal-RDW group (68.7%: 52.3%). The ORR of NSAA patients in the high-RDW group was better than that in the normal RDW group (75.8%: 60%). The 5-year OS of SAA/VSAA patients in the high-RDW group was significantly higher than the normal-RDW group (81.8%: 50.8%). CONCLUSIONThis is the first documentation on the prognostic value of RDW in AA patients receiving CsA treatment with long-term follow-up, which had shown that high RDW at diagnosis was a better prognostic factor.</description><identifier>ISSN: 1607-8454</identifier><identifier>EISSN: 1607-8454</identifier><identifier>DOI: 10.1080/16078454.2023.2240665</identifier><language>eng</language><publisher>Taylor & Francis Group</publisher><subject>androgen ; Aplastic anemia ; cyclosporin A ; prognostic factor ; red blood cell distribution width ; treatment</subject><ispartof>Hematology (Luxembourg), 2023-12, Vol.28 (1), p.2240665-2240665</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c347t-91c6f999d87257951ebac0870be0a6e8fc71a456f4567cd47141f1cc115553823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Zhang, Xiaotian</creatorcontrib><creatorcontrib>Zhang, Yanan</creatorcontrib><creatorcontrib>Liu, Fengan</creatorcontrib><creatorcontrib>Zhu, Jingjing</creatorcontrib><creatorcontrib>Liang, Xiuli</creatorcontrib><creatorcontrib>Shi, Xuedong</creatorcontrib><creatorcontrib>Han, Li</creatorcontrib><creatorcontrib>Xu, Kailin</creatorcontrib><creatorcontrib>Cheng, Hai</creatorcontrib><title>Red blood cell distribution width as a prognostic factor in patients with aplastic anemia treated with cyclosporin A plus androgen or cyclosporine A alone: a retrospective study</title><title>Hematology (Luxembourg)</title><description>OBJECTIVETo explore the prognostic value of red blood cell distribution width (RDW) in newly diagnosed aplastic anemia (AA) patients treated with cyclosporine A (CsA) plus androgen or CsA alone. METHODSWe retrospectively analyzed the clinical outcome of 220 patients with AA. According to the baseline level of RDW before treatment, the patients were divided into the high-RDW group (RDW ≥ 15%) and the normal-RDW group (RDW < 15%). RESULTSThe median RDW of non-severe AA (NSAA) and severe AA (SAA) patients was 15.65% and 15.35%, respectively; this were significantly higher than that of very severe AA (VSAA) patients (13.35%). With median follow-up being 46 months, AA patients in the high-RDW group showed better 5-year OS and PFS than the normal-RDW group (93%: 75.3%; 74.3%: 61%). There was a higher ORR in the high-RDW group than the normal-RDW group (68.7%: 52.3%). The ORR of NSAA patients in the high-RDW group was better than that in the normal RDW group (75.8%: 60%). The 5-year OS of SAA/VSAA patients in the high-RDW group was significantly higher than the normal-RDW group (81.8%: 50.8%). CONCLUSIONThis is the first documentation on the prognostic value of RDW in AA patients receiving CsA treatment with long-term follow-up, which had shown that high RDW at diagnosis was a better prognostic factor.</description><subject>androgen</subject><subject>Aplastic anemia</subject><subject>cyclosporin A</subject><subject>prognostic factor</subject><subject>red blood cell distribution width</subject><subject>treatment</subject><issn>1607-8454</issn><issn>1607-8454</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpNkd2KFDEQhRtRcF19BCGX3syYpPPr3bLourAgiF6H_FSvWTKdNkkr81i-oemZVfYiJNQ5-YqqMwxvCd4TrPB7IrBUjLM9xXTcU8qwEPzZcLHVd5vw_Mn75fCq1geMKcUSXwx_vkJALuUckIeUUIi1lejWFvOMfsfQfiBbkUVLyfdzri16NFnfckFxRottEeZWu3HzLcmeDHaGQ7SoFbCt00-iP_qU65JL_3aFlrR26Bw6FGbUYU9k6LpNeYYPvW2BVnodfIu_ANW2huPr4cVkU4U3j_fl8P3Tx2_Xn3d3X25ur6_udn5ksu008WLSWgclKZeaE3DWYyWxA2wFqMlLYhkXUz_SByYJIxPxnhDO-ajoeDncnrkh2wezlHiw5WiyjeZUyOXe2NLHTWCEdmTEgXvhKFNOOOf8CEEHzJXGynbWuzOrr_HnCrWZQ6zbvvuq8loNVXzUTEgqu5Wfrb4PXgtM_1sTbLa4zb-4zRa3eYx7_AvagKDC</recordid><startdate>20231231</startdate><enddate>20231231</enddate><creator>Zhang, Xiaotian</creator><creator>Zhang, Yanan</creator><creator>Liu, Fengan</creator><creator>Zhu, Jingjing</creator><creator>Liang, Xiuli</creator><creator>Shi, Xuedong</creator><creator>Han, Li</creator><creator>Xu, Kailin</creator><creator>Cheng, Hai</creator><general>Taylor & Francis Group</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>DOA</scope></search><sort><creationdate>20231231</creationdate><title>Red blood cell distribution width as a prognostic factor in patients with aplastic anemia treated with cyclosporin A plus androgen or cyclosporine A alone: a retrospective study</title><author>Zhang, Xiaotian ; Zhang, Yanan ; Liu, Fengan ; Zhu, Jingjing ; Liang, Xiuli ; Shi, Xuedong ; Han, Li ; Xu, Kailin ; Cheng, Hai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-91c6f999d87257951ebac0870be0a6e8fc71a456f4567cd47141f1cc115553823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>androgen</topic><topic>Aplastic anemia</topic><topic>cyclosporin A</topic><topic>prognostic factor</topic><topic>red blood cell distribution width</topic><topic>treatment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Xiaotian</creatorcontrib><creatorcontrib>Zhang, Yanan</creatorcontrib><creatorcontrib>Liu, Fengan</creatorcontrib><creatorcontrib>Zhu, Jingjing</creatorcontrib><creatorcontrib>Liang, Xiuli</creatorcontrib><creatorcontrib>Shi, Xuedong</creatorcontrib><creatorcontrib>Han, Li</creatorcontrib><creatorcontrib>Xu, Kailin</creatorcontrib><creatorcontrib>Cheng, Hai</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Directory of Open Access Journals</collection><jtitle>Hematology (Luxembourg)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Xiaotian</au><au>Zhang, Yanan</au><au>Liu, Fengan</au><au>Zhu, Jingjing</au><au>Liang, Xiuli</au><au>Shi, Xuedong</au><au>Han, Li</au><au>Xu, Kailin</au><au>Cheng, Hai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Red blood cell distribution width as a prognostic factor in patients with aplastic anemia treated with cyclosporin A plus androgen or cyclosporine A alone: a retrospective study</atitle><jtitle>Hematology (Luxembourg)</jtitle><date>2023-12-31</date><risdate>2023</risdate><volume>28</volume><issue>1</issue><spage>2240665</spage><epage>2240665</epage><pages>2240665-2240665</pages><issn>1607-8454</issn><eissn>1607-8454</eissn><abstract>OBJECTIVETo explore the prognostic value of red blood cell distribution width (RDW) in newly diagnosed aplastic anemia (AA) patients treated with cyclosporine A (CsA) plus androgen or CsA alone. METHODSWe retrospectively analyzed the clinical outcome of 220 patients with AA. According to the baseline level of RDW before treatment, the patients were divided into the high-RDW group (RDW ≥ 15%) and the normal-RDW group (RDW < 15%). RESULTSThe median RDW of non-severe AA (NSAA) and severe AA (SAA) patients was 15.65% and 15.35%, respectively; this were significantly higher than that of very severe AA (VSAA) patients (13.35%). With median follow-up being 46 months, AA patients in the high-RDW group showed better 5-year OS and PFS than the normal-RDW group (93%: 75.3%; 74.3%: 61%). There was a higher ORR in the high-RDW group than the normal-RDW group (68.7%: 52.3%). The ORR of NSAA patients in the high-RDW group was better than that in the normal RDW group (75.8%: 60%). The 5-year OS of SAA/VSAA patients in the high-RDW group was significantly higher than the normal-RDW group (81.8%: 50.8%). CONCLUSIONThis is the first documentation on the prognostic value of RDW in AA patients receiving CsA treatment with long-term follow-up, which had shown that high RDW at diagnosis was a better prognostic factor.</abstract><pub>Taylor & Francis Group</pub><doi>10.1080/16078454.2023.2240665</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
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subjects	androgen Aplastic anemia cyclosporin A prognostic factor red blood cell distribution width treatment
title	Red blood cell distribution width as a prognostic factor in patients with aplastic anemia treated with cyclosporin A plus androgen or cyclosporine A alone: a retrospective study
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