Distribution of Toxoplasma gondii IgM and IgG antibody seropositivity among age groups and gestational periods in pregnant women [version 3; peer review: 2 approved]

Background: Toxoplasmosis is a globally distributed parasitic disease. The present study aimed to estimate the prevalence and geographic distribution of toxoplasmosis as well as determine the percentage of toxoplasmosis-associated IgM and IgG seropositivity among different age groups. In addition, i...

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Bibliographic Details
Published in:F1000 research 2019-06, Vol.7, p.1823-1823
Main Authors: Sadiqui, Shahida, Shah, Syed Rafiq Hussain, Almugadam, Babiker Saad, Shakeela, Qismat, Ahmad, Shehzad
Format: Article
Language:English
Subjects:
Age groups
Animals
Conduction
Congenital diseases
Enzyme-linked immunosorbent assay
Fetuses
Food contamination & poisoning
Geographical distribution
Hospitals
Illnesses
Immunoglobulin G
Immunoglobulin M
Immunoglobulins
Infections
Laboratories
Medical research
Parasitic diseases
Pregnancy
Public health
Serology
Statistical analysis
Toxoplasma gondii
Toxoplasmosis
Womens health
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Summary:Background: Toxoplasmosis is a globally distributed parasitic disease. The present study aimed to estimate the prevalence and geographic distribution of toxoplasmosis as well as determine the percentage of toxoplasmosis-associated IgM and IgG seropositivity among different age groups. In addition, it aimed to estimate the proportion of toxoplasma IgM seropositivity among pregnancy trimesters. Methods: A total of 500 pregnant women were included in this study. From each participant, a 5-ml venous blood sample was collected and centrifuged to obtain serum that was tested for Toxoplasma gondii IgM and IgG antibodies using immunochromatographic testing and ELISA. Results: The overall seroprevalence of toxoplasmosis was 24.8%. Out of the total of 500 participants, only 8% had a serological marker of acute toxoplasmosis). There is a statistically significant difference in the seroprevalence of disease among the study areas. Amongst positive cases of every trimester, 54.34% of first trimester positive cases had a serologic marker for acute toxoplasmosis.  Conclusions: In this study, there is a high prevalence of toxoplasmosis. Therefore, it is necessary to test every pregnant woman for toxoplasmosis and distinguish the type of infection, as well as the conduction of public health education programs to generate the awareness.
ISSN:2046-1402
2046-1402
DOI:10.12688/f1000research.15344.3