The Effects of Lilium lancifolium Thunb. on the Alleviation of Joint Pain: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Arthritis is mainly a geriatric disease that causes joint pain and lowers the quality of life. This clinical trial was performed to evaluate the efficacy of Thunb. (HY-LL) in alleviating joint pain. Six candidate anti-inflammatory components including regaloside A were identified in HY-LL using HPLC...

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Published in:Life (Basel, Switzerland) Switzerland), 2024-09, Vol.14 (9), p.1136
Main Authors: Jeon, Soomin, Lee, Hayera, Lee, Jae-Ho, Lee, Kippeum, Hong, Dongki, Park, Soo-Dong, Shim, Jae-Jung, Lee, Jung-Lyoul, Lee, Jaehwan, Joo, Jong-Cheon
Format: Article
Language:English
Subjects:
Age related diseases
Aging
Alcoholism
Arthralgia
Arthritis
Biomarkers
Care and treatment
Cartilage
Chromatography
Clinical trials
Consumption
Disease
Drug abuse
Exercise therapy
Functional foods & nutraceuticals
health functional food
Hospitals
Hyaluronic acid
Hypertension
joint pain
Kinases
Knee
Lilium lancifolium
Liquid chromatography
Osteoarthritis
Pain
Placebos
Quality of life
Statistical analysis
Steroids
Substance abuse treatment
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Summary:Arthritis is mainly a geriatric disease that causes joint pain and lowers the quality of life. This clinical trial was performed to evaluate the efficacy of Thunb. (HY-LL) in alleviating joint pain. Six candidate anti-inflammatory components including regaloside A were identified in HY-LL using HPLC analysis. All participants were assigned to the HY-LL or the placebo group and took tablets twice a day for 12 weeks. As a result, pain VAS and K-WOMAC total scores significantly decreased after 12 weeks compared to the baseline in the HY-LL group, with a statistically significant difference between the two groups ( = 0.043, 0.043). The K-WOMAC sub-scores for pain and function showed a statistically significant improvement in the HY-LL group compared to the placebo group ( = 0.023, 0.047). Furthermore, the participants' overall quality of life improved after 12 weeks of HY-LL consumption ( = 0.024). However, no significant differences were observed in the blood biomarkers. Therefore, this study demonstrated the positive effect of 12 weeks of HY-LL consumption on joint pain and quality of life.
ISSN:2075-1729
2075-1729
DOI:10.3390/life14091136