Curcumin Inhibits The Adverse Effects of Sodium Arsenite in Mouse Epididymal Sperm

The aim of this study was to investigate the effects of curcumin on epididy- mal sperm parameters in adult male Navel Medical Research Institute (NMRI) mice ex- posed to sodium arsenite. In this experimental study, we divided the animals into four groups: control, sodium arsenite (5 mg/kg), curcumin...

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Bibliographic Details
Published in:International journal of fertility & sterility 2016-07, Vol.10 (2), p.245-252
Main Authors: Momeni, Hamid Reza, Eskandari, Najmeh
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Arsenic
curcumin
Infertility
Morphology
Motility
natural antioxidant
Original
Oxidative stress
Sodium
sodium arsenite
Sperm
Stains & staining
Variance analysis
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Summary:The aim of this study was to investigate the effects of curcumin on epididy- mal sperm parameters in adult male Navel Medical Research Institute (NMRI) mice ex- posed to sodium arsenite. In this experimental study, we divided the animals into four groups: control, sodium arsenite (5 mg/kg), curcumin (100 mg/kg) and curcumin+sodium arsenite. Exposures were performed by intraperitoneal injections for a 5-week period. After the exposure period, we recorded the animals' body and left testes weights. The left caudal epididymis was used to count the sperm number and analyze motility, viability, morphological abnormalities, acrosome reaction, DNA integrity, and histone-protamine replacement in the spermatozoa. One-way analysis of variance (ANOVA) followed by the Tukey's test was used to assess the statistical significance of the data with SPSS 16.0. P
ISSN:2008-076X
2008-0778
DOI:10.22074/ijfs.2016.4916