SLC22A1 And ATM Genes Polymorphisms Are Associated With The Risk Of Type 2 Diabetes Mellitus In Western Saudi Arabia: A Case-Control Study

• Published in: Application of clinical genetics 2019-01, Vol.12, p.213-219
• Main Authors: Altall, Rana M, Qusti, Safaa Y, Filimban, Najlaa, Alhozali, Amani M, Alotaibi, Najat A, Dallol, Ashraf, Chaudhary, Adeel G, Bakhashab, Sherin
• Format: Article
• Language: English
• Subjects: ataxia telangiectasia mutated; Original Research; single-nucleotide polymorphism; solute carrier family 22 member 1; type 2 diabetes mellitus
• ISSN: 1178-704X; 1178-704X
• DOI: 10.2147/TACG.S229952

Type 2 diabetes mellitus (T2DM) is a major global health problem that is progressively affected by genetic and environmental factors. The aim of this study is to determine the influence of solute carrier family 22 member 1 ( ) rs628031 and rs461473, and ataxia telangiectasia mutated ( ) rs11212617 polymorphisms on the risk of T2DM in Saudi Arabia by considering many parameters associated with glycemic control of T2DM, such as body mass index (BMI), fasting blood glucose, glycated hemoglobin (HbA1c), and triglyceride. In a case-control study, genomic DNA from controls and diabetic groups was isolated and genotyped for each single-nucleotide polymorphism. There were significant correlations between T2DM and both BMI and HbA1c. Significant associations between G/G and A/G genotypes of rs628031 and rs461473 variants of and high levels of HbA1c were detected. Therefore, G was predicted to be the risk allele among the assessed variants. A significant correlation was observed between A/A and A/C genotypes of the rs11212617 polymorphism of and elevated HbA1c. Relative risk calculation confirmed A to be the risk allele in the T2DM population. Our study showed the risk of the assessed and variants on glycemic control parameters in diabetic patients.