Target identification of hepatic fibrosis using Pien Tze Huang based on mRNA and lncRNA

Hepatic fibrosis is a spontaneous wound-healing response triggered by chronic liver injury. Pien Tze Huang (PZH), a traditional Chinese herbal medicine, has been widely used to treat various hepatic diseases in Asia. We used a CCl 4 -induced mouse model to establish a PZH group of hepatic fibrosis m...

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Bibliographic Details
Published in:Scientific reports 2021-08, Vol.11 (1), p.16980-16980, Article 16980
Main Authors: Zhu, Jinhang, Zhang, Di, Wang, Ting, Chen, Zhiliang, Chen, Luan, Wu, Hao, Huai, Cong, Sun, Jing, Zhang, Na, Wei, Muyun, Hong, Fei, Qin, Shengying
Format: Article
Language:English
Subjects:
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692/4020/4021/1607
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Alanine
Alanine transaminase
Animals
Aspartate aminotransferase
Biomarkers
Carbon tetrachloride
Cluster Analysis
Collagen
Drugs, Chinese Herbal - pharmacology
Drugs, Chinese Herbal - therapeutic use
Fibrosis
Gene expression
Gene Regulatory Networks
Herbal medicine
Humanities and Social Sciences
Immune system
Immune System - metabolism
Inflammation
Laboratories
Liver
Liver - physiopathology
Liver Cirrhosis - drug therapy
Liver Cirrhosis - genetics
Liver Cirrhosis - physiopathology
Liver diseases
Liver Function Tests
Male
Mass spectrometry
Mass spectroscopy
Mice
Mice, Inbred C57BL
multidisciplinary
Open Reading Frames - genetics
Proteins
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
Science
Science (multidisciplinary)
Scientific imaging
Staining and Labeling
Therapeutic targets
Wound healing
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Summary:Hepatic fibrosis is a spontaneous wound-healing response triggered by chronic liver injury. Pien Tze Huang (PZH), a traditional Chinese herbal medicine, has been widely used to treat various hepatic diseases in Asia. We used a CCl 4 -induced mouse model to establish a PZH group of hepatic fibrosis mice treated with PZH and a control group of hepatic fibrosis mice without any treatment. We performed RNA-seq and mass spectrometry sequencing to investigate the mechanism of the PZH response in hepatic fibrosis and identified multiple differentially expressed transcripts (DETs) and proteins (DEPs) that may be drug targets of PZH. Liver functional indices, including serum albumin (ALB), alanine aminotransferase (ALT) and aspartate aminotransferase (AST), were significantly decreased in the PZH treatment group ( P  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-96459-5