The Serum IL-6 Profile and Treg/Th17 Peripheral Cell Populations in Patients with Type 1 Diabetes

IL-6 is a pleiotropic cytokine involved in the regulation of the immune response, inflammation, and hematopoeisis. Its elevated levels are found in a range of autoimmune and chronic inflammatory diseases. IL-6 is also involved in regulation of the balance between two T cell subsets: Tregs and Th17,...

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Bibliographic Details
Published in:Mediators of Inflammation 2013-01, Vol.2013 (2013), p.533-539-049
Main Authors: Ryba-Stanislawowska, Monika, Skrzypkowska, Maria, Mysliwska, Jolanta, Mysliwiec, Malgorzata
Format: Article
Language:English
Subjects:
Adolescent
Cell interaction
Cell research
Cells, Cultured
Child
Diabetes
Diabetes Mellitus, Type 1 - immunology
Female
Flow Cytometry
Health aspects
Humans
Interleukin-6 - blood
Interleukins
Male
Physiological aspects
T-Lymphocyte Subsets - cytology
T-Lymphocytes, Regulatory - cytology
Th17 Cells - cytology
Type 1 diabetes
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Summary:IL-6 is a pleiotropic cytokine involved in the regulation of the immune response, inflammation, and hematopoeisis. Its elevated levels are found in a range of autoimmune and chronic inflammatory diseases. IL-6 is also involved in regulation of the balance between two T cell subsets: Tregs and Th17, which have contradictory functions in the control of inflammation. The present study provides a quantitative analysis regarding the Th17/Treg cell balance in peripheral blood of children with type 1 diabetes and its association with serum IL-6 level.
ISSN:0962-9351
1466-1861
DOI:10.1155/2013/205284