A web portal for exploring kinase-substrate interactions

Interactions between protein kinases and their substrates are critical for the modulation of complex signaling pathways. Currently, there is a large amount of information available about kinases and their substrates in disparate public databases. However, these data are difficult to interpret in the...

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Bibliographic Details
Published in:NPJ systems biology and applications 2024-10, Vol.10 (1), p.113-7, Article 113
Main Authors: Sekar, John A. P., Li, Yan Chak, Schlessinger, Avner, Pandey, Gaurav
Format: Article
Language:English
Subjects:
631/114/794
631/553/2710
631/553/2711
631/553/794
Bioinformatics
Biomedical and Life Sciences
Computational Biology - methods
Computational Biology/Bioinformatics
Computer Appl. in Life Sciences
Databases, Protein
Humans
Information systems
Internet
Kinases
Life Sciences
Phosphorylation
Post-translation
Protein kinase
Protein Kinases - metabolism
Protein Processing, Post-Translational
Proteins
Signal transduction
Signal Transduction - physiology
Software
Substrate Specificity
Systems Biology
User-Computer Interface
Web portals
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Summary:Interactions between protein kinases and their substrates are critical for the modulation of complex signaling pathways. Currently, there is a large amount of information available about kinases and their substrates in disparate public databases. However, these data are difficult to interpret in the context of cellular systems, which can be facilitated by examining interactions among multiple proteins at once, such as the network of interactions that constitute a signaling pathway. We present KiNet, a user-friendly web portal that integrates and shares information about kinase-substrate interactions from multiple databases of post-translational modifications. KiNet enables the visual exploration of these interactions in systems contexts, such as pathways, domain families, and custom protein set inputs, in an interactive fashion. We expect KiNet to be useful as a knowledge discovery tool for kinase-substrate interactions, and the aggregated KiNet dataset to be useful for protein kinase studies and systems-level analyses. The portal is available at https://kinet.kinametrix.com/ .
ISSN:2056-7189
2056-7189
DOI:10.1038/s41540-024-00442-5