In situ precise electrospinning of medical glue fibers as nonsuture dural repair with high sealing capability and flexibility

In this work, we propose an in situ precise electrospinning of medical glue fibers onto dural wound for improving sealing capability, avoiding tissue adhesion, and saving time in dural repair. N-octyl-2-cyanoacrylate, a commercial tissue adhesive (medical glue), can be electrospun into ultrathin fib...

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Bibliographic Details
Published in:International journal of nanomedicine 2016-01, Vol.11, p.4213-4220
Main Authors: Lv, Fu-Yan, Dong, Rui-Hua, Li, Zhao-Jian, Qin, Chong-Chong, Yan, Xu, He, Xiao-Xiao, Zhou, Yu, Yan, Shi-Ying, Long, Yun-Ze
Format: Article
Language:English
Subjects:
Adhesion
Adhesives
Animals
Antimicrobial agents
Biomedical materials
Cell Membrane - chemistry
Cyanoacrylates
Cyanoacrylates - chemistry
Cysts
Defects
Dura Mater - physiology
Dura Mater - surgery
electrospun fibers
Evaluation
Experiments
Flexibility
Fourier transforms
Gas-assisted electrospinning apparatus
Goats
In-situ repair dural
Laboratory animals
Medical research
Membranes
Meninges - physiology
Meninges - surgery
Microscopy, Electron, Scanning
Nanofibers - chemistry
Nanotechnology - instrumentation
Nanotechnology - methods
Nitriles
Original Research
Ovum - cytology
Polymers
Power supply
Simulation
Spectroscopy, Fourier Transform Infrared
Sutures
Textiles
Tissue Adhesions - prevention & control
Tissue Adhesives - chemistry
Tissue engineering
Wound healing
Wound Healing - physiology
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Description
Summary:In this work, we propose an in situ precise electrospinning of medical glue fibers onto dural wound for improving sealing capability, avoiding tissue adhesion, and saving time in dural repair. N-octyl-2-cyanoacrylate, a commercial tissue adhesive (medical glue), can be electrospun into ultrathin fibrous film with precise and homogeneous deposition by a gas-assisted electrospinning device. The self-assembled N-octyl-2-cyanoacrylate film shows high compactness and flexibility owing to its fibrous structure. Simulation experiments on egg membranes and goat meninges demonstrated that this technology can repair small membrane defects quickly and efficiently. This method may have potential application in dural repair, for example, working as an effective supplementary technique for conventional dura suture.
ISSN:1178-2013
1176-9114
1178-2013
DOI:10.2147/IJN.S113560