Genotypic profile of Streptococcus suis serotype 2 and clinical features of infection in humans, Thailand

To examine associations between clinical features of Streptococcus suis serotype 2 infections in humans in Thailand and genotypic profiles of isolates, we conducted a retrospective study during 2006-2008. Of 165 patients for whom bacterial cultures of blood, cerebrospinal fluid, or both were positiv...

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Bibliographic Details
Published in:Emerging infectious diseases 2011-05, Vol.17 (5), p.835-842
Main Authors: Kerdsin, Anusak, Dejsirilert, Surang, Puangpatra, Parichart, Sripakdee, Saowalak, Chumla, Koranan, Boonkerd, Nitsara, Polwichai, Pitimol, Tanimura, Susumu, Takeuchi, Dan, Nakayama, Tatsuya, Nakamura, Shota, Akeda, Yukihiro, Gottschalk, Marcelo, Sawanpanyalert, Pathom, Oishi, Kazunori
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
bacteria
Cluster Analysis
Contamination
Disease transmission
Endocarditis
Female
Food contamination
Genomics
Genotype
Healthcare industry software
Humans
Male
Medical research
Medicine, Experimental
Meningitis
Middle Aged
Molecular Epidemiology
Multilocus Sequence Typing
Phylogeography
Polysaccharides
Pork
Retrospective Studies
Risk factors
Seasons
sepsis
Septic shock
sequence typing
serotype 2
Streptococcal Infections - physiopathology
Streptococcus suis
Streptococcus suis - classification
Streptococcus suis - genetics
Thailand
Young Adult
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Summary:To examine associations between clinical features of Streptococcus suis serotype 2 infections in humans in Thailand and genotypic profiles of isolates, we conducted a retrospective study during 2006-2008. Of 165 patients for whom bacterial cultures of blood, cerebrospinal fluid, or both were positive for S. suis serotype 2, the major multilocus sequence types (STs) found were ST1 (62.4%) and ST104 (25.5%); the latter is unique to Thailand. Clinical features were examined for 158 patients. Infections were sporadic; case-fatality rate for adults was 9.5%, primarily in northern Thailand. Disease incidence peaked during the rainy season. Disease was classified as meningitis (58.9%) or nonmeningitis (41.1%, and included sepsis [35.4%] and others [5.7%]). Although ST1 strains were significantly associated with the meningitis category (p
ISSN:1080-6040
1080-6059
DOI:10.3201/eid1705.100754