Myelin oligodendrocyte glycoprotein antibody-associated disease with clinical presentation as multiple episodes of isolated meningeal involvement: a case report

• Published in: Journal of international medical research 2024-03, Vol.52 (3), p.3000605241233157-3000605241233157
• Main Authors: Wei, Xiaojie, Zhao, Chentong, Wang, Daqing, Han, Jingzhe
• Format: Article
• Language: English
• Subjects: Antibodies; Autoantibodies; Autoimmune Diseases; Exudates and Transudates; Glycoproteins; Headache; Humans; Male; Meningitis; Meningitis - diagnosis; Myelin-Oligodendrocyte Glycoprotein
• ISSN: 0300-0605; 1473-2300
• DOI: 10.1177/03000605241233157

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) constitutes a group of autoimmune neuroinflammatory conditions that are characterized by positive serum MOG-immunoglobulin G antibodies. The relationship between MOGAD and immune factors remains unclear. Herein, we report a man in his early 30s who initially presented symptoms of headache and low-grade fever persisting for 20 days. The patient experienced isolated meningitis onset and had recurrent meningitis as the primary clinical feature, which manifested as low-grade fever, headache, and neck rigidity. Although cranial magnetic resonance imaging showed no abnormalities, immunotherapy was promptly administered upon diagnosing MOGAD through positive MOG-specific antibody testing of cerebrospinal and serum fluids. Notably, the patient’s symptoms exhibited rapid improvement following treatment. Although meningitis is traditionally associated with infectious diseases, it can also occur in antibody-related autoimmune diseases that affect the central nervous system. Consequently, MOGAD should be considered in cases of aseptic meningitis with an unknown etiology, to facilitate definitive diagnosis and enhance patient prognosis.