Identification of A Putative T6SS Immunity Islet in Salmonella Typhi

Typhoid fever is a major global health problem and is the result of systemic infections caused by the human-adapted bacterial pathogen Salmonella enterica serovar Typhi (S. Typhi). The pathology underlying S. Typhi infections significantly differ from infections caused by broad host range serovars o...

Full description

Saved in:
Bibliographic Details
Published in:Pathogens (Basel) 2020-07, Vol.9 (7), p.559
Main Authors: Barretto, Luke, Fowler, Casey
Format: Article
Language:English
Subjects:
Bacteria
bacterial pathogenesis
Competition
Deoxyribonucleic acid
DNA
Fever
Food contamination & poisoning
Gastroenteritis
Gene loci
Genetic factors
Genomes
Genomics
Global health
Host range
Immune system
Immunity
Infections
Inflammation
interbacterial antagonism
Microbiota
Pathogenesis
Pathogens
Phylogenetics
Salmonella
Salmonella Typhi
Sequence analysis
T6SS
Toxins
type VI secretion systems
Typhoid
typhoid fever
Virulence
Waterborne diseases
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Typhoid fever is a major global health problem and is the result of systemic infections caused by the human-adapted bacterial pathogen Salmonella enterica serovar Typhi (S. Typhi). The pathology underlying S. Typhi infections significantly differ from infections caused by broad host range serovars of the same species, which are a common cause of gastroenteritis. Accordingly, identifying S. Typhi genetic factors that impart functionality absent from broad host range serovars offers insights into its unique biology. Here, we used an in-silico approach to explore the function of an uncharacterized 14-gene S. Typhi genomic islet. Our results indicated that this islet was specific to the S. enterica species, where it was encoded by the Typhi and Paratyphi A serovars, but was generally absent from non-typhoidal serovars. Evidence was gathered using comparative genomics and sequence analysis tools, and indicated that this islet was comprised of Type VI secretion system (T6SS) and contact-dependent growth inhibition (CDI) genes, the majority of which appeared to encode orphan immunity proteins that protected against the activities of effectors and toxins absent from the S. Typhi genome. We herein propose that this islet represents an immune system that protects S. Typhi against competing bacteria within the human gut.
ISSN:2076-0817
2076-0817
DOI:10.3390/pathogens9070559