In vitro analysis on inhibitory effect of sodium arsenite combined with astragaloside IV on HepG2 liver cancer cells

From the in vitro level, this paper explores the synergistic inhibitory effects and mechanisms of sodium arsenite (NaAsO2) and astragaloside IV(AS-IV) on HepG2 cells. By screening the optimal concentration of each drug, the authors tested the combined and separate effects of the two drugs on HepG2 c...

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Bibliographic Details
Published in:Alexandria engineering journal 2021-12, Vol.60 (6), p.5749-5764
Main Authors: Guo, Zhiwei, Xia, Yajuan, Hao, Guang, Gao, Zhenzhen, Li, Ran, Yang, Ying
Format: Article
Language:English
Subjects:
Astragaloside IV (AS-IV)
Combined treatment
Inhibitory effect
Liver cancer
Mechanism
Sodium Arsenite (NaAsO2)
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Summary:From the in vitro level, this paper explores the synergistic inhibitory effects and mechanisms of sodium arsenite (NaAsO2) and astragaloside IV(AS-IV) on HepG2 cells. By screening the optimal concentration of each drug, the authors tested the combined and separate effects of the two drugs on HepG2 cell proliferation, migration and invasion, cell cycle and apoptosis, as well as key genes and proteins of the PI3K/AKT/mTOR pathway (PI3K, p-PI3K, AKT, p-AKT, mTOR, and p-mTOR). The CCK-8 test and Transwell tests show that: the separate and joint uses of NaAsO2 and AS-IV reduced the viability and migration of cells to different degrees (p all 
ISSN:1110-0168
DOI:10.1016/j.aej.2021.03.043