First identification of bovine hepacivirus in wild boars

Hepatitis C virus (HCV) is a major cause of chronic hepatitis, cirrhosis and hepatocellular carcinoma in humans. Humans were long considered the only hosts of Hepacivirus . Recently HCV-like sequences have been found in several animal species. Hepaciviruses are considered species-specific but a wide...

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Bibliographic Details
Published in:Scientific reports 2022-07, Vol.12 (1), p.11678-11678, Article 11678
Main Authors: de Martinis, Claudio, Cardillo, Lorena, Esposito, Claudia, Viscardi, Maurizio, Barca, Lorella, Cavallo, Stefania, D’Alessio, Nicola, Martella, Vito, Fusco, Giovanna
Format: Article
Language:English
Subjects:
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Animal husbandry
Animal species
Breeding of animals
Cattle
Cirrhosis
Farms
Hepacivirus
Hepatitis
Hepatitis C
Hepatocellular carcinoma
Hogs
Homology
Host range
Humanities and Social Sciences
Liver
Liver cirrhosis
Livestock
Livestock farming
multidisciplinary
Nucleotide sequence
Phylogenetics
Phylogeny
Science
Science (multidisciplinary)
Species
Viruses
Zoonoses
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Summary:Hepatitis C virus (HCV) is a major cause of chronic hepatitis, cirrhosis and hepatocellular carcinoma in humans. Humans were long considered the only hosts of Hepacivirus . Recently HCV-like sequences have been found in several animal species. Hepaciviruses are considered species-specific but a wider host range and a zoonotic role has been hypothesized. We report the first detection of bovine hepacivirus (BovHepV) sequences in wild boars. A total of 310 wild boars hunted in Campania region were investigated with a pan-hepacivirus nested-PCR protocol for the NS3 gene. Hepacivirus RNA was detected in 5.8% of the animals. Sequence and phylogenetic analysis showed high homology with BovHepV subtype F, with nucleotide identity of 99%. The positive wild boars were georeferenced, revealing high density of livestock farms, with no clear distinction between animal husbandry and hunting areas. These findings might suggest the ability of BovHepV to cross the host-species barrier and infect wild boars.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-15928-7