Perinatal mortality and its association with antenatal care visit, maternal tetanus toxoid immunization and partograph utilization in Ethiopia: a meta-analysis

• Published in: Scientific reports 2021-10, Vol.11 (1), p.19641-17, Article 19641
• Main Authors: Desta, Melaku, Akalu, Tadesse Yirga, Alamneh, Yoseph Merkeb, Talie, Asmare, Alemu, Addisu Alehegn, Tessema, Zenaw, Yibeltal, Desalegn, Alamneh, Alehegn Aderaw, Ketema, Daniel Bekele, Shiferaw, Wondimeneh Shibabaw, Getaneh, Temesgen
• Format: Article
• Language: English
• Subjects: 692/499; 692/699; 692/700; Abortion, Induced; Cause of Death; Disease Susceptibility; Ethiopia - epidemiology; Female; Heterogeneity; Humanities and Social Sciences; Humans; Immunization; Infant, Newborn; Meta-analysis; Mortality; multidisciplinary; Odds Ratio; Perinatal Death - etiology; Perinatal Mortality; Pregnancy; Prenatal care; Prenatal Care - standards; Prenatal Care - statistics & numerical data; Public health; Public Health Surveillance; Risk reduction; Science; Science (multidisciplinary); Statistical analysis; Tetanus; Tetanus Toxoid - adverse effects; Tetanus Toxoid - immunology; Vaccination; Vaccination - adverse effects; Vaccination - methods; Vaccines
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-98996-5

Despite remarkable progress in the reduction of under-five mortality; perinatal mortality is the major public health problem in Africa. In Ethiopia, the study findings on perinatal mortality and its predictors were inconsistent. Therefore, this systematic review and meta-analysis estimated the pooled perinatal mortality, and its association with antenatal care visit, maternal tetanus toxoid immunization, and partograph monitoring. International databases like PubMed, SCOPUS, Google Scholar and Science Direct were systematically searched. I squared statistics was used to determine the levels of heterogeneity across studies and the pooled estimate was computed using a random-effect model. The meta-analysis showed that a pooled prevalence of perinatal mortality in Ethiopia was 6.00% (95% CI 5.00%, 7.00%). The highest proportion of perinatal mortality was a stillbirth, 5.00% (95% CI 4.00%, 7.00%). Women who had antenatal care visit [OR = 0.20 (95% CI 0.12, 0.34)], maternal tetanus toxoid immunization [OR = 0.43 (95% CI 0.24, 0.77)] and partograph monitoring [POR = 0.22 (95% CI 0.06, 0.76)] reduced the risk of perinatal mortality. Whereas, previous history of perinatal mortality [POR = 7.95 (95% CI 5.59, 11.30)] and abortion history (POR = 2.02 (95% CI 1.18, 3.46)) significantly increased the risk of perinatal mortality. Therefore, antenatal care visit, maternal tetanus toxoid vaccination uptake, and partograph utilization should be an area of improvements to reduce perinatal mortality.