Opioidergic Signaling-A Neglected, Yet Potentially Important Player in Atopic Dermatitis

• Published in: International journal of molecular sciences 2022-04, Vol.23 (8), p.4140
• Main Authors: Ádám, Dorottya, Arany, József, Tóth, Kinga Fanni, Tóth, Balázs István, Szöllősi, Attila Gábor, Oláh, Attila
• Format: Article
• Language: English
• Subjects: Administration, Cutaneous; Atopic dermatitis; atopic dermatitis (AD); Child; cutaneous barrier; Dermatitis; Dermatitis, Atopic; Disease; Eczema; Endorphins; Humans; Immune system; Immunology; inflammation; itch; Ligands; Microbiota; Mutation; Narcotics; Older people; Pathogenesis; Peptides; Proteins; Receptors, Opioid - metabolism; Review; Signal Transduction; Skin - metabolism; Skin diseases; Therapeutic applications; Therapeutic targets; δ-opioid receptor (DOR); κ-opioid receptor (KOR)
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms23084140

Atopic dermatitis (AD) is one of the most common skin diseases, the prevalence of which is especially high among children. Although our understanding about its pathogenesis has substantially grown in recent years, and hence, several novel therapeutic targets have been successfully exploited in the management of the disease, we still lack curative treatments for it. Thus, there is an unmet societal demand to identify further details of its pathogenesis to thereby pave the way for novel therapeutic approaches with favorable side effect profiles. It is commonly accepted that dysfunction of the complex cutaneous barrier plays a central role in the development of AD; therefore, the signaling pathways involved in the regulation of this quite complex process are likely to be involved in the pathogenesis of the disease and can provide novel, promising, yet unexplored therapeutic targets. Thus, in the current review, we aim to summarize the available potentially AD-relevant data regarding one such signaling pathway, namely cutaneous opioidergic signaling.