Vascular Response to Graded Angiotensin II Infusion in Offspring Subjected to High-Salt Drinking Water during Pregnancy: The Effect of Blood Pressure, Heart Rate, Urine Output, Endothelial Permeability, and Gender

Introduction. Rennin-angiotensin system and salt diet play important roles in blood pressure control. We hypothesized that the high-salt intake during pregnancy influences the degree of angiotensin-dependent control of the blood pressure in adult offspring. Methods. Female Wistar rats in two groups...

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Bibliographic Details
Published in:International Journal of Vascular Medicine 2014-01, Vol.2014 (2014), p.153-160
Main Authors: Pezeshki, Zahra, Eshraghi-Jazi, Fatemeh, Nematbakhsh, Mehdi
Format: Article
Language:English
Subjects:
Animals
Blood pressure
Carotid arteries
Catheters
Coronary vessels
Diet
Drinking water
Females
Gender
Heart rate
Hypertension
Kidneys
Mothers
Permeability
Pregnancy
Saline water
Salt
Sodium
Urine
Veins & arteries
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Summary:Introduction. Rennin-angiotensin system and salt diet play important roles in blood pressure control. We hypothesized that the high-salt intake during pregnancy influences the degree of angiotensin-dependent control of the blood pressure in adult offspring. Methods. Female Wistar rats in two groups (A and B) were subjected to drink tap and salt water, respectively, during pregnancy. The offspring were divided into four groups as male and female offspring from group A (groups 1 and 2) and from group B (groups 3 and 4). In anesthetized matured offspring mean arterial pressure (MAP), heart rate and urine output were measured in response to angiotensin II (AngII) (0-1000 ng/kg/min, iv) infusion. Results. An increase in MAP was detected in mothers with salt drinking water (P
ISSN:2090-2824
2090-2832
DOI:10.1155/2014/876527