The effect of Helicobacter pylori eradication on prognosis of postoperative early gastric cancer: a multicenter study

• Published in: World journal of surgical oncology 2021-09, Vol.19 (1), p.1-285, Article 285
• Main Authors: Wang, Liang, Wang, Jinfeng, Li, Sha, Bai, Fei, Xie, Hailong, Shan, Hanguo, Liu, Zhuo, Ma, Tiexiang, Tang, Xiayu, Tang, Haibing, Qin, Ang, Lei, Sanlin, Zuo, Chaohui
• Format: Article
• Language: English
• Subjects: Age; Cancer; Cancer therapies; Care and treatment; Classification; Confidence intervals; Early gastric cancer (EGC); Gastrectomy; Gastric cancer; Gastrointestinal surgery; Helicobacter infections; Helicobacter pylori; Helicobacter pylori (H. pylori); Lymphatic system; Medical prognosis; Metastases; Metastasis; Multivariate analysis; Patient outcomes; Patients; Postoperative period; Prognosis; Risk analysis; Risk factors; Stomach cancer; Survival; Survival analysis; Ulcers
• ISSN: 1477-7819; 1477-7819
• DOI: 10.1186/s12957-021-02343-x

Objective To investigate the effect of Helicobacter pylori (H. pylori) eradication on the prognosis of postoperative early gastric cancer (EGC). Methods This is a retrospective study based on data from 6 hospitals. We identified 429 patients with EGC who underwent curative gastrectomy from January 2010 to December 2016. All of the patients were tested for H. pylori. Patients were divided into two groups, the successful H. pylori eradication group (group A, 268 patients) and the non-H. pylori eradication group (group B, 161 patients), for calculating the disease-free survival (DFS) and overall survival (OS) of each group. Result Positive node metastasis (hazard ratio (HR), 3.13; 95% confidence interval (CI), 1.84-5.32; P < 0.001), undifferentiated type (HR, 2.54; 95% CI, 1.51-4.28; P < 0.001), and non-H. pylori eradication (HR, 1.73; 95% CI, 1.08-2.77; P = 0.023) were statistically significantly independent risk factors of recurrence. Patient's age [greater than or equai to]60 years old (HR, 3.32; 95% CI, 2.00-5.53; P < 0.001), positive node metastasis (HR, 3.71; 95% CI, 2.25-6.12; P < 0.001), undifferentiated type (HR, 3.06; 95% CI, 1.79-5.23; P < 0.001), and non-H. pylori eradication (HR, 1.83; 95% CI, 1.11-3.02; P = 0.018) were statistically significantly independent risk factors of overall survival. Conclusion H. pylori eradication treatment could prevent the recurrence of postoperative EGC to prolong the overall survival of patients with EGC. Keywords: Early gastric cancer (EGC), Helicobacter pylori (H. pylori), Prognosis, Risk factors