Greater susceptibility of girls to airborne Benzo[a]pyrene for obesity-associated childhood asthma

Sexually dimorphic risk of obesity-associated asthma is posited to accelerate around puberty. Yet, the role of air pollution on the lean and obese asthmatic children has never been examined. To compare whether a unit exposure to airborne benzo[a]pyrene (B[a]P) is associated with altered risks of ast...

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Bibliographic Details
Published in:Environment international 2018-12, Vol.121 (Pt 1), p.308-316
Main Authors: Choi, Hyunok, Dostal, Miroslav, Pastorkova, Anna, Rossner, Pavel, Sram, Radim J., Ho, Shuk-Mei
Format: Article
Language:English
Subjects:
Adolescent
Air Pollutants - toxicity
Air pollution
Asthma
Asthma - chemically induced
Asthma - etiology
Benzo(a)pyrene - toxicity
Benzo[a]pyrene
Child
Female
Humans
Logistic Models
Male
Obesity
Pediatric Obesity - complications
Polycyclic aromatic hydrocarbon
Sex Characteristics
Sex-dimorphic
Sexual Maturation
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Summary:Sexually dimorphic risk of obesity-associated asthma is posited to accelerate around puberty. Yet, the role of air pollution on the lean and obese asthmatic children has never been examined. To compare whether a unit exposure to airborne benzo[a]pyrene (B[a]P) is associated with altered risks of asthma across the overweight/obese (OV/OB) control, lean asthmatic, and OV/OB asthmatic children, respectively, compared to the lean controls, before and after adjusting for oxidant stress markers (i.e. 15‑F2t‑IsoP, 8‑oxo‑dG, and Carbonyl). Asthmatic and healthy control children, recruited from polluted urban and rural areas, were matched to ambient concentration of B[a]P. A unit increase in B[a]P and multinomial logistic regression on OV/OB control, lean asthmatic, and OV/OB asthma were compared across the sex- and age-groups. The median B[a]P was associated with a linear increase among the female children, according to OV/OB and asthma, respectively, and together, compared to the lean control girls (p = 0.001). While B[a]P was associated with positive relationship with 15‑F2t‑IsoP level among the OV/OB boys, the same exposure-outcome association was inverse among the OV/OB girls. One natural log-unit increase in ambient B[a]P was associated with 10.5-times greater odds (95% CI, 2.6–39.6; p = 0.001) the adolescent OV/OB boys, compared to the unit odds among the lean controls. In contrast, the adolescent OV/OB girls were associated with highest adjusted odds of the asthma (aOR = 15.4; 95% CI, 2.9–29.1; p 
ISSN:0160-4120
1873-6750
DOI:10.1016/j.envint.2018.08.061