Blood Eosinophil Endotypes across Asthma and Chronic Obstructive Pulmonary Disease (COPD)

Background. Eosinophils were common inflammatory cells involved in the occurrence and development of various inflammatory diseases. Multiple recent studies have pointed to the increasingly important role of eosinophils in respiratory diseases. This article aims to compare the expression differences...

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Bibliographic Details
Published in:Canadian respiratory journal 2022-10, Vol.2022, p.1-9
Main Authors: Luo, Jia-Ying, Chen, Hui-An, Feng, Yuan-Yu, Chen, Ye-Peng, Lei, Xiang-Cheng, Guo, Shuang-Lin, Huang, Xiao-Bin, Liang, Zhi-Man, Li, Ning, Sun, Bao-Qing
Format: Article
Language:English
Subjects:
Age
Airway management
Asthma
Blood
China
Chronic obstructive pulmonary disease
Cytokines
Development and progression
Diseases
Dyspnea
Eosinophils
Gender
Health aspects
Hospital patients
Inflammation
Lung diseases, Obstructive
Medical colleges
Medical records
Medical research
Medicine, Experimental
Neutrophils
Patients
Physiological aspects
Plasma
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Summary:Background. Eosinophils were common inflammatory cells involved in the occurrence and development of various inflammatory diseases. Multiple recent studies have pointed to the increasingly important role of eosinophils in respiratory diseases. This article aims to compare the expression differences of blood eosinophil counts between asthma, chronic obstructive pulmonary disease (COPD), and asthma-COPD overlap (ACO). Methods. Patients with asthma, COPD, and ACO who were seen in the First Affiliated Hospital of Guangzhou Medical University from January 2012 to June 2019 were included. We collected information such as age, gender, diagnosis, the eosinophil counts from the medical records. Moreover, the levels of 10 cytokines in the plasma of each group were detected by using the Meso Scale Discovery method. Results. We included 9787 patients with asthma, 15806 patients with COPD, and 831 ACO patients. From our results, it can be first found that eosinophil levels were age-related in the three diseases (asthma and ACO: p
ISSN:1198-2241
1916-7245
DOI:10.1155/2022/9656278