Overview of Neutralizing Antibodies and Their Potential in COVID-19

The antibody response to respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a major focus of COVID-19 research due to its clinical relevance and importance in vaccine and therapeutic development. Neutralizing antibody (NAb) evaluations are useful for the determination of individual or herd imm...

Full description

Saved in:
Bibliographic Details
Published in:Vaccines (Basel) 2021-11, Vol.9 (12), p.1376
Main Authors: Morales-Núñez, José Javier, Muñoz-Valle, José Francisco, Torres-Hernández, Paola Carolina, Hernández-Bello, Jorge
Format: Article
Language:English
Subjects:
Antibodies
Antibody response
Antigens
Coronaviruses
COVID-19
COVID-19 vaccines
Cytotoxicity
Enzymes
Glycoproteins
Herd immunity
Infections
monoclonal antibodies
neutralization assays
Neutralizing
neutralizing antibodies
Pathogens
Peptides
Proteins
Review
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Vaccine efficacy
Vaccines
Viral infections
Viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The antibody response to respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a major focus of COVID-19 research due to its clinical relevance and importance in vaccine and therapeutic development. Neutralizing antibody (NAb) evaluations are useful for the determination of individual or herd immunity against SARS-CoV-2, vaccine efficacy, and humoral protective response longevity, as well as supporting donor selection criteria for convalescent plasma therapy. In the current manuscript, we review the essential concepts of NAbs, examining their concept, mechanisms of action, production, and the techniques used for their detection; as well as presenting an overview of the clinical use of antibodies in COVID-19.
ISSN:2076-393X
2076-393X
DOI:10.3390/vaccines9121376