Ultrasonic actuation of a fine-needle improves biopsy yield

Despite the ubiquitous use over the past 150 years, the functions of the current medical needle are facilitated only by mechanical shear and cutting by the needle tip, i.e. the lancet. In this study, we demonstrate how nonlinear ultrasonics (NLU) extends the functionality of the medical needle far b...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2021-04, Vol.11 (1), p.8234-15, Article 8234
Main Authors: Perra, Emanuele, Lampsijärvi, Eetu, Barreto, Gonçalo, Arif, Muhammad, Puranen, Tuomas, Hæggström, Edward, Pritzker, Kenneth P. H., Nieminen, Heikki J.
Format: Article
Language:English
Subjects:
639/166/985
639/766/25/3927
Animals
Biopsy
Biopsy, Fine-Needle - instrumentation
Biopsy, Fine-Needle - methods
Cattle
Cavitation
Drug Delivery Systems - instrumentation
Drug Delivery Systems - methods
Gene transfer
Gene Transfer Techniques - instrumentation
Humanities and Social Sciences
Humans
Hypodermic needles
Minimally Invasive Surgical Procedures - instrumentation
Minimally Invasive Surgical Procedures - methods
multidisciplinary
Nanoparticles
Needles
Phantoms, Imaging
Science
Science (multidisciplinary)
Surgery, Computer-Assisted - instrumentation
Surgery, Computer-Assisted - methods
Ultrasonics
Ultrasonics - instrumentation
Ultrasonics - methods
Ultrasonography, Interventional - instrumentation
Ultrasonography, Interventional - methods
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Despite the ubiquitous use over the past 150 years, the functions of the current medical needle are facilitated only by mechanical shear and cutting by the needle tip, i.e. the lancet. In this study, we demonstrate how nonlinear ultrasonics (NLU) extends the functionality of the medical needle far beyond its present capability. The NLU actions were found to be localized to the proximity of the needle tip, the SonoLancet, but the effects extend to several millimeters from the physical needle boundary. The observed nonlinear phenomena, transient cavitation, fluid streams, translation of micro- and nanoparticles and atomization, were quantitatively characterized. In the fine-needle biopsy application, the SonoLancet contributed to obtaining tissue cores with an increase in tissue yield by 3–6× in different tissue types compared to conventional needle biopsy technique using the same 21G needle. In conclusion, the SonoLancet could be of interest to several other medical applications, including drug or gene delivery, cell modulation, and minimally invasive surgical procedures.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-87303-x