Association of insulin resistance surrogate indices and erectile dysfunction: a systematic review and meta-analysis

Erectile dysfunction (ED) has been linked to insulin resistance (IR), with various surrogate indices being used to assess this association. This systematic review and meta-analysis aimed to evaluate the relationship between IR indices and the incidence and severity of ED. A comprehensive search acro...

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Published in:Reproductive biology and endocrinology 2024-11, Vol.22 (1), p.148-14, Article 148
Main Authors: Jalali, Sayeh, Zareshahi, Negar, Behnoush, Amir Hossein, Azarboo, Alireza, Shirinezhad, Amirhossein, Hosseini, Seyyed Yasin, Javidan, Amin, Ghaseminejad-Raeini, Amirhossein
Format: Article
Language:English
Subjects:
Analysis
Biological markers
Biomarkers - blood
Blood Glucose - analysis
Blood Glucose - metabolism
Complications and side effects
Development and progression
Erectile dysfunction
Erectile Dysfunction - blood
Erectile Dysfunction - diagnosis
Erectile Dysfunction - epidemiology
Erectile Dysfunction - physiopathology
Glucose metabolism
HOMA-IR
Humans
Impotence
Insulin resistance
Insulin Resistance - physiology
Male
Medical research
Medicine, Experimental
Metabolic syndrome
Review
Risk factors
Surrogate indices
Triglyceride-glucose index
Triglycerides - blood
Type 2 diabetes
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Summary:Erectile dysfunction (ED) has been linked to insulin resistance (IR), with various surrogate indices being used to assess this association. This systematic review and meta-analysis aimed to evaluate the relationship between IR indices and the incidence and severity of ED. A comprehensive search across PubMed, Embase, Web of Science, and Scopus was carried out. Required data were extracted and meta-analyzed. The Newcastle-Ottawa Scale (NOS) was employed to evaluate the studies' risk of bias. Sensitivity analyses and meta-regressions were conducted to explore heterogeneity and the impact of confounding variables. Seventeen studies with a total of 3810 patients with ED and 8252 without ED were included. Meta-analysis revealed that males with ED had significantly higher levels of Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) (SMD = 0.59, 95% CI [0.15, 1.03], I  = 82%, P 
ISSN:1477-7827
1477-7827
DOI:10.1186/s12958-024-01317-4