Expression of NMDA receptor-dependent LTP in the hippocampus: bridging the divide

A consensus has famously yet to emerge on the locus and mechanisms underlying the expression of the canonical NMDA receptor-dependent form of LTP. An objective assessment of the evidence leads us to conclude that both presynaptic and postsynaptic expression mechanisms contribute to this type of syna...

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Bibliographic Details
Published in:Molecular brain 2013-01, Vol.6 (1), p.5-5
Main Authors: Bliss, Tim V P, Collingridge, Graham L
Format: Article
Language:English
Subjects:
Animal cognition
Animals
Brain
Experiments
Glutamic acid receptors (ionotropic)
Hippocampus
Hippocampus - physiology
Humans
Long-term potentiation
Long-Term Potentiation - physiology
Methyl aspartate
Models, Biological
N-Methyl-D-aspartic acid receptors
Neural networks
Neurology
Neurons
Plasticity (synaptic)
Receptors, N-Methyl-D-Aspartate - metabolism
Review
Synapses - physiology
Tetanus
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Summary:A consensus has famously yet to emerge on the locus and mechanisms underlying the expression of the canonical NMDA receptor-dependent form of LTP. An objective assessment of the evidence leads us to conclude that both presynaptic and postsynaptic expression mechanisms contribute to this type of synaptic plasticity.
ISSN:1756-6606
1756-6606
DOI:10.1186/1756-6606-6-5