Pancreatic and duodenal homeobox-1 in pancreatic ductal adenocarcinoma and diabetes mellitus

Diabetes mellitus and pancreatic ductal adenocarcinoma are two common diseases worldwidely which are both derived from different components of pancreas. The pancreatic and duodenal homeobox-1 (PDX1) is an essential transcription factor for the early development of pancreas that is required for the d...

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Bibliographic Details
Published in:Chinese medical journal 2020-02, Vol.133 (3), p.344-350
Main Authors: Tang, Zhen-Chu, Chu, Yi, Tan, Yu-Yong, Li, Jing, Gao, Shan
Format: Article
Language:English
Subjects:
Animals
Carcinoma, Pancreatic Ductal - drug therapy
Carcinoma, Pancreatic Ductal - etiology
Diabetes Mellitus - drug therapy
Diabetes Mellitus - etiology
Homeodomain Proteins - antagonists & inhibitors
Homeodomain Proteins - physiology
Humans
Insulin-Secreting Cells - physiology
Pancreatic Neoplasms - drug therapy
Pancreatic Neoplasms - etiology
Review
Trans-Activators - antagonists & inhibitors
Trans-Activators - physiology
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Summary:Diabetes mellitus and pancreatic ductal adenocarcinoma are two common diseases worldwidely which are both derived from different components of pancreas. The pancreatic and duodenal homeobox-1 (PDX1) is an essential transcription factor for the early development of pancreas that is required for the differentiation of all pancreatic cell lineages. Current evidence suggests an important role of PDX1 in both the origin and progression of pancreatic diseases. In this review, we discussed recent studies of PDX1 in diabetes mellitus and pancreatic cancer, and the therapeutic strategies derived from this transcription factor.
ISSN:0366-6999
2542-5641
DOI:10.1097/CM9.0000000000000628