Changes in Adipokines following Laparoscopic Roux-en-Y Gastric Bypass Surgery in Chinese Individuals with Type 2 Diabetes Mellitus and BMI of 22–30 kg·m−2

• Published in: International journal of endocrinology 2013-01, Vol.2013 (2013), p.1-6
• Main Authors: Liu, Yiqun, Shrestha, Chandrama, Mo, Zhaohui, Xiong, Jing, Zhu, Shai-Hong, He, Honghui
• Format: Article
• Language: English
• Subjects: Adipocytes; Body mass index; Clinical Study; Diabetes; Endocrinology; Gastrointestinal surgery; Glucose; Hospitals; Insulin resistance; Kinases; Metabolism; Obesity; Ostomy; Plasma; Proteins; Statistical analysis; Studies; Weight control
• ISSN: 1687-8337; 1687-8345
• DOI: 10.1155/2013/240971

Aims. Although altered endocrine changes following bariatric surgery in morbidly obese patients with diabetes have been demonstrated by previous studies, little is known about their effects on low BMI patients of T2DM. We investigated the changes in adipokines and sICAM-1 in Chinese subjects with low BMI and T2DM after LRYGB and explored their relationship with postsurgical insulin sensitivity. Methods. Plasma levels of adiponectin, sICAM-1, fasting glucose, glycated hemoglobin, and fasting insulin and serum levels of visfatin were measured before and at three months after LRYGB in 33 T2DM patients with BMI of 22–30 kg·m−2. Results. Significant reductions in anthropometric measurements and indicators of glucose and lipid metabolism and moderate reductions in insulin resistance and fasting insulin were observed at three months after LRYGB. Postoperative adiponectin level (P