Presence of DQ2.2 Associated with DQ2.5 Increases the Risk for Celiac Disease

Background. Celiac disease (CD) is a genetically determined immune-mediated disorder in which gluten immunogenic peptides are presented to CD4 T cells by HLA-DQ2.5, DQ8, DQ2.2, and their combinations. Our aim is to establish a risk gradient for celiac disease based on HLA-DQ profile in a brazilian r...

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Bibliographic Details
Published in:Autoimmune Diseases 2016-01, Vol.2016 (2016), p.8-13
Main Authors: Nóbrega, Yanna Karla de Medeiros, Almeida, Fernanda Coutinho de, Uenishi, Rosa Harumi, Pratesi, Riccardo, Gandolfi, Lenora, Almeida, Lucas Malta, Selleski, Nicole
Format: Article
Language:English
Subjects:
Antibodies
Biopsy
CD4 antigen
Celiac disease
Gastroenterology
Genetic aspects
Genotype & phenotype
Genotypes
Gluten
Haplotypes
Histocompatibility antigen HLA
Histocompatibility antigens
HLA histocompatibility antigens
Immunogenicity
Lymphocytes T
Pediatrics
Risk factors
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Summary:Background. Celiac disease (CD) is a genetically determined immune-mediated disorder in which gluten immunogenic peptides are presented to CD4 T cells by HLA-DQ2.5, DQ8, DQ2.2, and their combinations. Our aim is to establish a risk gradient for celiac disease based on HLA-DQ profile in a brazilian representative population and the relevance of DQ2.2 in celiac disease development. Materials and Methods. 237 celiac patients and 237 controls (both groups with 164 females and 73 males) were included. All samples were tested for the presence of predisposing HLA-DQ alleles using the PCR-SSP method. Results were considered significant when p
ISSN:2090-0430
2090-0422
2090-0430
DOI:10.1155/2016/5409653