Anti-Human Immunodeficiency Virus-1 Property of Thai Herbal Extract Kerra

Kerra™, a Thai traditional herbal medicine derived from the "Tak-Ka-Si-La Scripture" and composed of nine medicinal plants, has demonstrated potential antiviral properties against HIV. This study investigated the inhibitory effects of Kerra™ on HIV-1 reverse transcriptase (RT) and its abil...

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Bibliographic Details
Published in:Pharmaceuticals (Basel, Switzerland) Switzerland), 2024-07, Vol.17 (7), p.917
Main Authors: Saehlee, Siriwan, Seetaha, Supaphorn, Klankaew, Wiwat, Srathong, Pussadee, Choowongkomon, Kiattawee, Choengpanya, Khuanjarat
Format: Article
Language:English
Subjects:
Flowers & plants
Herbal medicine
HIV-1
molecular docking
Phytochemicals
reverse transcriptase
Thai herbal extract
Viruses
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Summary:Kerra™, a Thai traditional herbal medicine derived from the "Tak-Ka-Si-La Scripture" and composed of nine medicinal plants, has demonstrated potential antiviral properties against HIV. This study investigated the inhibitory effects of Kerra™ on HIV-1 reverse transcriptase (RT) and its ability to prevent pseudo-HIV viral infection in HEK293 cells. The results showed that Kerra™ extract achieved a 95.73 ± 4.24% relative inhibition of HIV-1 RT, with an IC value of 42.66 ± 8.74 µg/mL. Docking studies revealed that key phytochemicals in Kerra™, such as oleamide, formononetin, and biochanin A, interact with several residues in the RT non-nucleoside binding pocket, contributing to their inhibitory effects. Furthermore, Kerra™ was able to reduce pseudo-HIV infection in HEK293 cells at a concentration of 10 µg/mL, suggesting its potential as a supplementary treatment for HIV.
ISSN:1424-8247
1424-8247
DOI:10.3390/ph17070917