Papillary and peripapillary vascular densities and corresponding correlation with peripapillary retinal thicknesses using optical coherence tomography angiography in healthy children and adolescents

To evaluate the peripapillary retinal thickness (PPRT), vascular density (PPVD), and disc vascular density (PVD) and their correlations in normal healthy children using optical coherence tomography angiography (OCTA). This was a cross-sectional study of 70 eyes from 36 normal healthy children aged 6...

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Bibliographic Details
Published in:Scientific reports 2024-03, Vol.14 (1), p.5372-9, Article 5372
Main Authors: Ghassemi, Fariba, Salari, Farhad, Hatami, Vahid, Mohebbi, Masoumeh, Sabour, Siamak
Format: Article
Language:English
Subjects:
631/378/2613/1786
692/698/1688/512/2613/1786
Adolescent
Angiography
Child
Children
Cross-Sectional Studies
Female
Humanities and Social Sciences
Humans
Male
Medical imaging
Microvascular Density
multidisciplinary
Optic nerve
Retina
Retina - diagnostic imaging
Science
Science (multidisciplinary)
Tomography
Tomography, Optical Coherence
Variance analysis
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Summary:To evaluate the peripapillary retinal thickness (PPRT), vascular density (PPVD), and disc vascular density (PVD) and their correlations in normal healthy children using optical coherence tomography angiography (OCTA). This was a cross-sectional study of 70 eyes from 36 normal healthy children aged 6–18 years who performed optic nerve head scans using OCTA. The PPRT included the peripapillary nerve fiber layer (PP-RNFLT), inner retina (PP-IRT), middle retinal thickness, and outer retinal thicknesses. The PP-RNFLT and PP-IRT were not significantly different between males and females. Superior nasal peripapillary RNFLT and IRT were significantly affected by age (ANOVA, P  > 0.05). The PP-IRT and PP-RNFLT were lower in the 7–11 years old group in comparison with the other 3 groups (Post hoc Tukey test, P value  0.05). PPRT was not correlated with PVD, PPVD, superficial and deep retinal vascular densities, and choroidal vascular density. This study demonstrated that PPRT appears to change during growth in childhood. Superior nasal PPRT was affected more in the groups, decreasing from less than 7 years old to 7–11 years old and then back to pre-reduction values after 11 years old.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-50934-3